Kijima Natsumi, Uzawa Yui, Hirai Yuri, Nojima Yusuke, Aoyama Jun, Takahashi Hideaki, Arai Yasuhiro, Sano Daisuke, Nishimura Goshi, Oridate Nobuhiko, Fujii Satoshi
Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Head Neck. 2025 Jun;47(6):1769-1778. doi: 10.1002/hed.28090. Epub 2025 Jan 31.
The AJCC cutoff value of 2 mm for the extranodal extension (ENE) distance was determined from an analysis of patients with or without adjuvant therapy. The purpose of this study was to find out the ENE distance that reflects prognosis only in patients with head and neck squamous cell carcinoma (SCC) who received adjuvant therapy.
The ENE distance was defined for 109 patients who underwent surgery for SCC of larynx or hypopharynx as a primary tumor.
To standardize patient conditions, only 26 patients who received additional postoperative treatment were analyzed. Receiver operating characteristic analysis of the ENE distance for overall survival (OS) and recurrence-free survival (RFS) yielded a cutoff value of 4250 μm. Multivariate analysis showed that the ENE distance was an independent poor prognostic factor for OS and RFS.
The optimal ENE distance cutoff for OS and RFS in postoperatively treated patients was 4250 μm.
美国癌症联合委员会（AJCC）确定的结外侵犯（ENE）距离2毫米的临界值是通过对接受或未接受辅助治疗的患者进行分析得出的。本研究的目的是找出仅在接受辅助治疗的头颈部鳞状细胞癌（SCC）患者中反映预后的ENE距离。
对109例因喉或下咽SCC作为原发肿瘤而接受手术的患者定义ENE距离。
为使患者情况标准化，仅分析了26例接受术后额外治疗的患者。对总生存期（OS）和无复发生存期（RFS）的ENE距离进行的受试者工作特征分析得出临界值为4250μm。多因素分析表明，ENE距离是OS和RFS的独立不良预后因素。
术后治疗患者中OS和RFS的最佳ENE距离临界值为4250μm。
