Fan Yuhang, Yang Qingmei, Lin Yifeng, Fu Xiaoying, Shu Jing
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Center for Reproductive Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 315300, Zhejiang, China.
Arch Gynecol Obstet. 2025 Mar;311(3):841-850. doi: 10.1007/s00404-025-07965-0. Epub 2025 Feb 1.
Endometriosis significantly impacts the physical and mental health of women of reproductive age. While some patients can achieve pregnancy through surgery or in vitro fertilization (IVF), many still struggle with IVF failure due to poor oocyte quality. This presents a major clinical challenge that requires immediate attention. The causes of oocyte quality decline in endometriosis patients are diverse and have not yet been definitively identified. Furthermore, effective diagnostic mechanisms and therapeutic strategies remain elusive. To provide possible clinical solutions to improve pregnancy rates in patients with endometriosis, this review evaluates the current literature on the impact of endometriosis on oocyte quality, the possible mechanisms and management strategies of endometriosis leading to poor oocyte quality.
子宫内膜异位症对育龄女性的身心健康有显著影响。虽然一些患者可通过手术或体外受精（IVF）实现妊娠，但许多患者仍因卵母细胞质量差而面临IVF失败的困扰。这是一个亟待关注的重大临床挑战。子宫内膜异位症患者卵母细胞质量下降的原因多种多样，尚未明确。此外，有效的诊断机制和治疗策略仍难以捉摸。为了提供可能的临床解决方案以提高子宫内膜异位症患者的妊娠率，本综述评估了当前关于子宫内膜异位症对卵母细胞质量的影响、导致卵母细胞质量差的子宫内膜异位症的可能机制及管理策略的文献。
