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用于特发性声门下狭窄的滑动式喉气管固定术。

Slide laryngotracheopexy for idiopathic subglottic stenosis.

作者信息

Tóbiás Zoltán, Bach Ádám, Szakács László, Csanády Miklós, Ambrus Andrea, Rovó László

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Albert Szent-Györgyi Faculty of Medicine, University of Szeged, Szeged, Hungary.

, Tisza Lajos krt. 111, Szeged, 6721, Hungary.

出版信息

Eur Arch Otorhinolaryngol. 2025 Apr;282(4):1981-1988. doi: 10.1007/s00405-025-09226-x. Epub 2025 Feb 1.

Abstract

OBJECTIVES

Idiopathic subglottic stenosis (iSGS) is a rare fibroinflammatory disorder characterized by scar tissue formation in the subglottic and tracheal regions. This study evaluated the long-term outcomes of a novel, single-step surgical technique that redefines the glottic and subglottic airway using local tracheal grafts.

METHODS

Thirteen patients (2 male and 11 female) diagnosed with iSGS who underwent slide laryngotracheopexy were enrolled in this study. The diagnosis of iSGS was confirmed through endoscopic assessment, CT scanning, and autoimmune blood testing. Patients completed post-operative Voice Handicap Index (VHI), Quality of Life (QoL), and MD Anderson Dysphagia Inventory (MDADI) questionnaires, and spirometry assessments were conducted.

RESULTS

All patients were successfully extubated in the operating room following surgery. None of the patients required intensive care unit treatment. The average hospital stay was 14 days. A temporary tracheotomy was needed in one case because of excessive crusting. Adjuvant endolaryngeal laser surgery was performed in three cases. In one case, mitomycin-C therapy was administered to treat granulation. Post-operative quality of life (QoL) assessment, peak inspiratory flow (PIF), and scores from the MDADI and VHI questionnaires were 9.0 (± 2.2), 2.8 l/s (± 0.83), 95.6 (± 4.3), and 18.7 (± 13.4), respectively.

CONCLUSION

Slide laryngotracheopexy was a safe and dependable technique for cases classified as Cotton-Myers II-IV grade iSGS. The use of a tracheal flap was advantageous to ensure optimal mucosal function. Slide laryngotracheopexy may be employed following multiple endolaryngeal interventions, whereas adjuvant CO laser surgery or mitomycin-c therapy may be considered in cases involving granulation tissue formation.

STUDY DESIGN

Retrospective case series review.

摘要

目的

特发性声门下狭窄(iSGS)是一种罕见的纤维炎症性疾病,其特征是声门下和气管区域形成瘢痕组织。本研究评估了一种新型单步手术技术的长期疗效,该技术使用局部气管移植物重新定义声门和声门下气道。

方法

本研究纳入了13例诊断为iSGS并接受滑动式喉气管固定术的患者(2例男性,11例女性)。通过内镜评估、CT扫描和自身免疫性血液检测确诊iSGS。患者完成术后嗓音障碍指数(VHI)、生活质量(QoL)和MD安德森吞咽障碍量表(MDADI)问卷调查,并进行肺活量测定评估。

结果

所有患者术后均在手术室成功拔管。无一例患者需要重症监护病房治疗。平均住院时间为14天。1例因结痂过多需要临时气管切开术。3例患者接受了辅助性喉内激光手术。1例患者接受丝裂霉素-C治疗以治疗肉芽组织。术后生活质量(QoL)评估、吸气峰值流速(PIF)以及MDADI和VHI问卷调查得分分别为9.0(±2.2)、2.8升/秒(±0.83)、95.6(±4.3)和18.7(±13.4)。

结论

对于分类为Cotton-Myers II-IV级的iSGS病例,滑动式喉气管固定术是一种安全可靠的技术。使用气管瓣有利于确保最佳的黏膜功能。在多次喉内干预后可采用滑动式喉气管固定术,而在涉及肉芽组织形成的病例中可考虑辅助性CO激光手术或丝裂霉素-C治疗。

研究设计

回顾性病例系列研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388c/11950051/e6623a3294f2/405_2025_9226_Fig1_HTML.jpg

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