一种用于大脑尺度上淀粉样蛋白动态变化及阿尔茨海默病治疗的网络聚合模型。

Brennan Georgia S, Goriely Alain

Mathematical Institute, University of Oxford, Andrew Wiles Building, Woodstock Rd, Oxford, OX2 6GG, UK.

J Math Biol. 2025 Feb 1;90(2):22. doi: 10.1007/s00285-024-02179-5.

Neurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an autocatalytic protein progression. The growth and transport of these assemblies depend on various mechanisms that can be targeted therapeutically. Here, we use spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain to study the effect of different drugs on whole-brain Alzheimer's disease progression.

神经退行性疾病与特定蛋白质组装成寡聚体和纤维状聚集体有关。在大脑层面，这些蛋白质聚集体可在大脑中扩散并播种到其他区域，形成自催化的蛋白质进展。这些聚集体的生长和运输取决于多种可用于治疗靶向的机制。在这里，我们使用空间扩展的成核 - 聚集 - 碎片化模型来研究大脑中朊病毒样神经退行性蛋白质传播的动力学，以探讨不同药物对全脑阿尔茨海默病进展的影响。