Ragab Eman M, Gamal Doaa M El, El-Najjar Fares F, Elkomy Hager A, Ragab Mahmoud A, Elantary Mariam A, Basyouni Omar M, Moustafa Sherif M, El-Naggar Shimaa A, Elsherbiny Abeer S
Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Chemistry/Biochemistry Division, chemistry department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Discov Oncol. 2025 Feb 1;16(1):107. doi: 10.1007/s12672-025-01846-3.
Pancreatic cancer is an extremely deadly illness for which there are few reliable treatments. Recent research indicates that malignant tumors are highly variable and consist of a tiny subset of unique cancer cells, known as cancer stem cells (CSCs), which are responsible for the beginning and spread of tumors. These cells are typically identified by the expression of specific cell surface markers. A population of pancreatic cancer stem cells with aberrantly active developmental signaling pathways has been identified in recent studies of human pancreatic tumors. Among these Notch signaling pathway has been identified as a key regulator of CSCs self-renewal, making it an attractive target for therapeutic intervention. Chrysin-loaded polylactic acid (PLA) as polymeric nanoparticles systems have been growing interest in using as platforms for improved drug delivery. This review aims to explore innovative strategies for targeted therapy and optimized drug delivery in pancreatic CSCs by manipulating the Notch pathway and leveraging PLA-based drug delivery systems. Furthermore, we will assess the capability of PLA nanoparticles to enhance the bioavailability and effectiveness of gemcitabine in pancreatic cancer cells. The insights gained from this review have the potential to contribute to the development of novel treatment approaches that combine targeted therapy with advanced drug delivery utilizing biodegradable polymeric nanoparticles.
胰腺癌是一种极其致命的疾病，几乎没有可靠的治疗方法。最近的研究表明，恶性肿瘤具有高度变异性，由一小部分独特的癌细胞组成，即癌症干细胞（CSCs），它们负责肿瘤的起始和扩散。这些细胞通常通过特定细胞表面标志物的表达来识别。在近期对人类胰腺肿瘤的研究中，已鉴定出一群具有异常活跃发育信号通路的胰腺癌干细胞。其中，Notch信号通路已被确定为癌症干细胞自我更新的关键调节因子，使其成为治疗干预的一个有吸引力的靶点。载有白杨素的聚乳酸（PLA）作为聚合物纳米颗粒系统，在用作改善药物递送的平台方面越来越受到关注。这篇综述旨在通过操纵Notch信号通路和利用基于PLA的药物递送系统，探索针对胰腺癌干细胞的靶向治疗和优化药物递送的创新策略。此外，我们将评估PLA纳米颗粒提高吉西他滨在胰腺癌细胞中的生物利用度和有效性的能力。从这篇综述中获得的见解有可能有助于开发新的治疗方法，将靶向治疗与利用可生物降解聚合物纳米颗粒的先进药物递送相结合。
