El Brouzi Mohamed Yassine, Adadi Najlae, Lamtai Mouloud, Boulahfa Hafsa, Zghari Oussama, Fath Nada, Rezqaoui Ayoub, El Hamzaoui Abdelghafour, Njimat Smail, El Hessni Aboubaker, Mesfioui Abdelhalem
Laboratory of Biology and Health, Neurosciences, Neuro-Immunology and Behaviour Unit, Faculty of Science, Ibn Tofail University, Kenitra, Morocco.
Higher Institute of Nursing and Health Professions of Dakhla, Dakhla, Morocco.
Biol Trace Elem Res. 2025 Feb 1. doi: 10.1007/s12011-025-04528-x.
Nickel (Ni) exposure is linked to numerous health issues, including dermatitis, immunotoxicity, and cancer. Emerging evidence suggests Ni may cross the blood-brain barrier, accumulating in the brain and causing neuroinflammation, oxidative stress, and neuronal apoptosis. Herein, we investigated the effect of Ni exposure through the intraperitoneal route, studying the Ni effect in subacute and chronic toxicity, on various health parameters in Wistar rats. Rats were randomly divided into four groups (n = 10 per group): two groups received a daily intraperitoneal injection of NiCl₂ at a dose of 0.25 mg/kg for subacute (21 days) or chronic (60 days) exposure periods, while the other two groups were treated with NaCl solution (0.9%) as a control for equivalent durations. The study assessed behavioral, biochemical, hematological, immunological, neurobiochemical, and histopathological effects over 21 and 60 days. Neurobehavioral tests, blood and tissue analyses, and organ examinations were conducted. This study demonstrates that Ni bioaccumulation in subacute and chronic exposure has significant health impacts in Wistar rats, including hematological, immunological, biochemical, AchE activity, neuroinflammatory, oxidative stress, and neurobehavioral changes. Chronic exposure results in higher Ni accumulation, particularly in the brain, causing neurotoxicity, inflammation, and behavioral disorders such as anxiety, depression, and memory impairment. The findings highlight the importance of limiting Ni exposure to prevent adverse health effects.
镍（Ni）暴露与众多健康问题相关，包括皮炎、免疫毒性和癌症。新出现的证据表明，镍可能会穿过血脑屏障，在大脑中蓄积并引发神经炎症、氧化应激和神经元凋亡。在此，我们通过腹腔注射途径研究了镍暴露的影响，考察了镍在亚急性和慢性毒性方面对Wistar大鼠各种健康参数的作用。大鼠被随机分为四组（每组n = 10）：两组分别在亚急性（21天）或慢性（60天）暴露期每天腹腔注射剂量为0.25 mg/kg的NiCl₂，而另外两组用NaCl溶液（0.9%）作为对照，处理相同时长。该研究在21天和60天内评估了行为、生化、血液学、免疫学、神经生化和组织病理学影响。进行了神经行为测试、血液和组织分析以及器官检查。本研究表明，亚急性和慢性暴露中的镍生物蓄积对Wistar大鼠有显著的健康影响，包括血液学、免疫学、生化、乙酰胆碱酯酶活性、神经炎症、氧化应激和神经行为变化。慢性暴露导致更高的镍蓄积，尤其是在大脑中，引起神经毒性、炎症以及焦虑、抑郁和记忆障碍等行为紊乱。这些发现凸显了限制镍暴露以预防不良健康影响的重要性。
