• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新冠病毒病患者中抗核抗体的流行率：与健康对照相比显著升高了2.5倍。

Prevalence of anti-nuclear antibodies in COVID-19 patients: a remarkable 2.5-fold rise compared to healthy controls.

作者信息

Dişli Faruk, Yıldız Sedat

机构信息

Faculty of Physiotherapy and Rehabilitation Department of Basic Physiotherapy, Bingöl University, Bingöl, Türkiye.

Faculty of Medicine, Department of Physiology, İnönü University, Malatya, Türkiye.

出版信息

Ir J Med Sci. 2025 Apr;194(2):717-724. doi: 10.1007/s11845-025-03886-8. Epub 2025 Feb 1.

DOI:10.1007/s11845-025-03886-8
PMID:39891878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12031873/
Abstract

BACKGROUND

The SARS-CoV-2 virus, responsible for COVID-19, has the potential to induce the formation of antibodies that target self-antigens. This study aimed to investigate the prevalence of antinuclear antibodies (ANA), the most common type of autoantibody, in both healthy individuals and those recovered from COVID-19.

METHODS

This retrospective study involved 400 participants (200 with COVID-19 and 200 healthy controls), aged 18 to 60 years, without any chronic diseases, including autoimmune conditions. Analyses were performed using three different ANA ELISA test kits (anti-dsDNA, anti-ENA, and anti-Hep-2 nucleus tests) that were developed and validated.

RESULTS

Among the 200 healthy individuals, 38 (19%) tested positive for dsDNA, 37 (18.5%) for ENA, and 30 (15%) for Hep-2 nucleus antibodies. The rates of ANA positivity were significantly higher in individuals with COVID-19, with 97 (48.5%) positive for dsDNA, 81 (40.5%) for ENA, and 84 (42%) for Hep-2 nucleus antibodies (p < 0.05).

CONCLUSION

One in every two to three individuals with COVID-19 exhibited ANA positivity, indicating that the SARS-CoV-2 virus poses a significant risk regarding autoimmunity. Furthermore, the incidence of ANA in healthy individuals was observed to be higher than the literature average.

摘要

背景

导致COVID-19的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒有可能诱导针对自身抗原的抗体形成。本研究旨在调查健康个体和COVID-19康复者中最常见的自身抗体类型——抗核抗体（ANA）的流行情况。

方法

这项回顾性研究纳入了400名年龄在18至60岁之间、无任何慢性疾病（包括自身免疫性疾病）的参与者（200名COVID-19患者和200名健康对照）。使用三种经过开发和验证的不同ANA酶联免疫吸附试验试剂盒（抗双链DNA、抗可提取核抗原和抗人喉癌上皮细胞系核试验）进行分析。

结果

在200名健康个体中，38人（19%）抗双链DNA检测呈阳性，37人（18.5%）抗可提取核抗原检测呈阳性，30人（15%）抗人喉癌上皮细胞系核抗体检测呈阳性。COVID-19患者的ANA阳性率显著更高，其中97人（48.5%）抗双链DNA阳性，81人（40.5%）抗可提取核抗原阳性，84人（42%）抗人喉癌上皮细胞系核抗体阳性（p<0.05）。

结论

每两到三名COVID-19患者中就有一人表现出ANA阳性，这表明SARS-CoV-2病毒在自身免疫方面构成重大风险。此外，观察到健康个体中ANA的发生率高于文献平均水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/ad6c8facda02/11845_2025_3886_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/0aff84e3ea60/11845_2025_3886_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/4d3b947c586e/11845_2025_3886_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/05766f8ca6ff/11845_2025_3886_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/ad6c8facda02/11845_2025_3886_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/0aff84e3ea60/11845_2025_3886_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/4d3b947c586e/11845_2025_3886_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/05766f8ca6ff/11845_2025_3886_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73e7/12031873/ad6c8facda02/11845_2025_3886_Fig4_HTML.jpg

相似文献

1
Prevalence of anti-nuclear antibodies in COVID-19 patients: a remarkable 2.5-fold rise compared to healthy controls.新冠病毒病患者中抗核抗体的流行率：与健康对照相比显著升高了2.5倍。
Ir J Med Sci. 2025 Apr;194(2):717-724. doi: 10.1007/s11845-025-03886-8. Epub 2025 Feb 1.
2
Anti-ENA antibody profiles in patients with hepatitis C virus infection.丙型肝炎病毒感染患者的抗可提取核抗原抗体谱
J Clin Lab Anal. 2018 Mar;32(3). doi: 10.1002/jcla.22279. Epub 2017 Jun 12.
3
Detection of antinuclear antibodies (ANA), antibodies to double stranded DNA (anti-dsDNA) and antibodies to extractable nuclear antigens (anti-ENA) in Greek patients.希腊患者中抗核抗体（ANA）、双链DNA抗体（抗dsDNA）和可提取核抗原抗体（抗ENA）的检测
Clin Lab. 2013;59(3-4):283-91. doi: 10.7754/clin.lab.2012.120327.
4
High prevalence of long COVID in anti-TPO positive euthyroid individuals with strongly elevated SARS-CoV-2-specific T cell responses and moderately raised anti-spike IgG levels 23 months post-infection.抗 TPO 阳性甲状腺功能正常个体中 COVID-19 长期后遗症的高发生率与强烈升高的 SARS-CoV-2 特异性 T 细胞反应和中度升高的抗刺突 IgG 水平相关，这些个体在感染后 23 个月。
Front Immunol. 2024 Oct 10;15:1448659. doi: 10.3389/fimmu.2024.1448659. eCollection 2024.
5
High Sensitivity Detection of Anti-DFS70 Antibodies by Radioimmunoprecipitation Assay (RIPA).用放射性免疫沉淀分析（RIPA）法高灵敏度检测抗 DFS70 抗体。
Clin Lab. 2020 May 1;66(5). doi: 10.7754/Clin.Lab.2019.191016.
6
Retrospective evaluation of "Rods and Rings" pattern detected in the anti-nuclear antibody (ANA) indirect immunofluorescence (IIF) test.回顾性评估抗核抗体（ANA）间接免疫荧光（IIF）试验中检测到的“Rods and Rings”模式。
Front Immunol. 2024 Jun 7;15:1359030. doi: 10.3389/fimmu.2024.1359030. eCollection 2024.
7
[THE CLINICAL INFORMATIVENESS OF AUTOMATED METHODS OF SCREENING DETECTION OF ANTI-NUCLEAR ANTIBODIES USING INDIRECT REACTION OF IMMUNE FLUORESCENCE, ENZYME-LINKED IMMUNOSORBENT ASSAY AND MULTIPLEX XMAP TECHNOLOGY UNDER SYSTEMIC LUPUS ERYTHEMATOSUS].[基于间接免疫荧光反应、酶联免疫吸附测定和多重XMAP技术的自动化抗核抗体筛查检测方法在系统性红斑狼疮中的临床信息价值]
Klin Lab Diagn. 2017 Mar;62(3):173-7.
8
Utility of anti-Sm, anti-RNP, anti-Ro/SS-A, and anti-La/SS-B (extractable nuclear antigens) detected by enzyme-linked immunosorbent assay for the diagnosis of systemic lupus erythematosus.酶联免疫吸附测定法检测抗Sm、抗RNP、抗Ro/SS - A和抗La/SS - B（可提取核抗原）在系统性红斑狼疮诊断中的应用价值。
Arthritis Rheum. 1996 Jun;39(6):1055-61. doi: 10.1002/art.1780390626.
9
Autoantibody profile and clinical patterns in 619 Italian patients with cutaneous lupus erythematosus.619 例意大利盘状红斑狼疮患者的自身抗体谱及临床特征。
J Eur Acad Dermatol Venereol. 2019 Apr;33(4):742-752. doi: 10.1111/jdv.15147. Epub 2018 Jul 12.
10
High prevalence of antinuclear antibodies in children with thyroid autoimmunity.甲状腺自身免疫患儿中抗核抗体的高患病率。
J Immunol Res. 2014;2014:150239. doi: 10.1155/2014/150239. Epub 2014 Feb 24.

本文引用的文献

1
The development of anticyclic citrullinated peptide (anti-CCP) antibody following severe COVID-19.新冠病毒感染后出现抗环瓜氨酸肽（anti-CCP）抗体。
Immun Inflamm Dis. 2024 May;12(5):e1276. doi: 10.1002/iid3.1276.
2
Molecular mimicry and autoimmunity in the time of COVID-19.在 COVID-19 时代的分子模拟和自身免疫。
J Autoimmun. 2023 Sep;139:103070. doi: 10.1016/j.jaut.2023.103070. Epub 2023 Jun 12.
3
Overview of autoantibodies in COVID-19 convalescents.新型冠状病毒肺炎康复者体内自身抗体概述。
J Med Virol. 2023 Jun;95(6):e28864. doi: 10.1002/jmv.28864.
4
Autoimmunity and Immunodeficiency in Severe SARS-CoV-2 Infection and Prolonged COVID-19.重症新型冠状病毒肺炎感染及新冠后综合征中的自身免疫与免疫缺陷
Curr Issues Mol Biol. 2022 Dec 21;45(1):33-50. doi: 10.3390/cimb45010003.
5
Molecular Mimicry between SARS-CoV-2 and Human Endocrinocytes: A Prerequisite of Post-COVID-19 Endocrine Autoimmunity?新型冠状病毒与人类内分泌细胞之间的分子模拟：新冠后内分泌自身免疫的一个先决条件？
Pathophysiology. 2022 Aug 25;29(3):486-494. doi: 10.3390/pathophysiology29030039.
6
Increasing Prevalence of Antinuclear Antibodies in the United States.美国抗核抗体的患病率不断增加。
Arthritis Rheumatol. 2022 Dec;74(12):2032-2041. doi: 10.1002/art.42330. Epub 2022 Oct 19.
7
Incidence of newly diagnosed diabetes after Covid-19.新冠病毒感染后新发糖尿病的发病率。
Diabetologia. 2022 Jun;65(6):949-954. doi: 10.1007/s00125-022-05670-0. Epub 2022 Mar 16.
8
New Onset of Autoimmune Diseases Following COVID-19 Diagnosis.新冠病毒感染后自身免疫性疾病的新发病例。
Cells. 2021 Dec 20;10(12):3592. doi: 10.3390/cells10123592.
9
The intersection of COVID-19 and autoimmunity.COVID-19 与自身免疫的交集。
J Clin Invest. 2021 Dec 15;131(24). doi: 10.1172/JCI154886.
10
COVID-19: adrenal response and molecular mimicry.新型冠状病毒肺炎：肾上腺反应与分子模拟
Isr Med Assoc J. 2021 Oct;23(10):618-619.