The genus Aubl. (Rubiaceae): source of bioactive compounds.

The genus Aubl. belong to the Rubiaceae family, which is distributed in Tropical America. A compressive bibliographic survey was carried out on the uses in traditional medicine, bioactive properties, and secondary metabolites isolated from the genus. The Web of Science, Science Direct, Pubmed, Scopus and Google Scholar databases were utilised between the years 1990 -2024. The genus is used in traditional medicine for purposes such as antimalarial, haemostatic, dewormer, hypertension, hepatitis, antiulcerogenic, and so on. Bioactivities have been reported for the extracts and isolated compounds such as anti-plasmodial activity, antiprotozoal, antioxidant, anti-inflammatory, antimycobacterial, toxicity, and so on. As well as, anticancer activity, nitric oxide, acetylcholinesterase, and monoamine oxidase inhibitory activity, anthelmintic and others, respectively. Approximately 106 metabolites were isolated from the genus, including iridoids, flavonoids, triterpenes, coumarins, phytosterols, phenolic acids, and alkaloids. The analysis of the collected information shows that the genus is an important source of bioactive compounds. The monoterpene indole alkaloids class represents the largest number of isolated compounds. This review provides a foundation on the phytochemical components, uses in traditional medicine, and biological activities of extracts and isolated compounds of the genus Aubl., thereby contributing to future studies in the search for discoveries and potential applications.