骨骼肌神经支配：作为神经肌肉接头动态和运动单位重塑调节因子的活性氧物质。
Skeletal muscle innervation: Reactive oxygen species as regulators of neuromuscular junction dynamics and motor unit remodeling.
作者信息
Guzman Steve D, Brooks Susan V
机构信息
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
出版信息
Free Radic Biol Med. 2025 Mar 16;230:58-65. doi: 10.1016/j.freeradbiomed.2025.01.053. Epub 2025 Jan 30.
This review explores the intricate processes of motor unit remodeling with a specific focus on the influence of reactive oxygen species (ROS) and oxidative stress on the primary cellular components: nerves/axons, muscle fibers, and muscle-resident glial cells. Emphasizing the role of redox biology, we highlight how oxidative stress impacts motor unit adaptation, injury response, and aging. By synthesizing findings from recent studies with seminal works, including investigations of myelin and terminal Schwann cells and neuromuscular junction (NMJ) dynamics, this review provides a comprehensive understanding of the molecular mechanisms underpinning motor unit maintenance and repair. The goal is to elucidate how oxidative stress influences these processes and to explore potential therapeutic strategies for neuromuscular disorders.
本综述探讨了运动单位重塑的复杂过程，特别关注活性氧（ROS）和氧化应激对主要细胞成分的影响：神经/轴突、肌纤维和肌肉驻留神经胶质细胞。我们强调氧化还原生物学的作用，突出氧化应激如何影响运动单位适应、损伤反应和衰老。通过综合近期研究与开创性研究的结果，包括对髓鞘和终末施万细胞以及神经肌肉接头（NMJ）动力学的研究，本综述全面理解了运动单位维持和修复的分子机制。目的是阐明氧化应激如何影响这些过程，并探索针对神经肌肉疾病的潜在治疗策略。
Zotero 插件