Hu Rui, Du Wei, Tan Fan, Wu Yong, Yang Chun, Wang Weiwei, Chen Wen, Miao Yanwei
Department of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning province 116000, China; Department of Radiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei province 442000, China.
Department of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning province 116000, China.
Brain Res Bull. 2025 Mar;222:111230. doi: 10.1016/j.brainresbull.2025.111230. Epub 2025 Jan 30.
To investigate the change of dynamic amplitude of low-frequency fluctuation (dALFF) and dynamic fractional amplitude of low-frequency fluctuation (dfALFF) in patients with attention-deficit/hyperactivity disorder (ADHD), and to explore whether dALFF/dfALFF can be used to distinguish ADHD from health controls (HCs).
Forty-eight cases of clinically confirmed ADHD and forty-four cases of HCs were included in the present study. It was compared to the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF), as well as the dynamic indicators dALFF and dfALFF. We investigated the relationship between clinical and dynamic indicators, and additionally performed voxel-based functional connectivity (FC) analysis. Finally, we developed an auxiliary diagnosis model.
Brain regions with increased dALFF variability of ADHD were located in right middle frontal gyrus (MFG), left inferior parietal lobe (IPL) and superior parietal gyrus (SPG) compared with HCs. Meanwhile, increased dfALFF variability was also observed in left lingual gyrus (LING), right MFG and left middle occipital gyrus (MOG) in ADHD compared to HCs. Neuropsychological scale scores correlated with some dALFF and dfALFF indicators. Reduced FC was found between the left IPL and right cerebellum crus II in ADHD compared with HCs. With dALFF and dfALFF variability as features, we achieved a good area under the curve and an accurate classification.
This study offers new valuable insights into the cerebral dysfunction associated with ADHD from the standpoint of dynamic local brain activity. The understanding of dALFF/dfALFF variability can contribute to the comprehension of neurophysiological mechanisms and potentially aid in the diagnosis of ADHD.
探讨注意缺陷多动障碍（ADHD）患者低频波动动态幅度（dALFF）和低频波动动态分数幅度（dfALFF）的变化，并探究dALFF/dfALFF是否可用于区分ADHD患者与健康对照（HCs）。
本研究纳入48例临床确诊的ADHD患者和44例HCs。比较了低频波动幅度（ALFF）、低频波动分数幅度（fALFF）以及动态指标dALFF和dfALFF。我们研究了临床指标与动态指标之间的关系，并额外进行了基于体素的功能连接（FC）分析。最后，我们建立了一个辅助诊断模型。
与HCs相比，ADHD患者dALFF变异性增加的脑区位于右侧额中回（MFG）、左侧顶下小叶（IPL）和顶上小叶（SPG）。同时，与HCs相比，ADHD患者左侧舌回（LING）、右侧MFG和左侧枕中回（MOG）的dfALFF变异性也增加。神经心理量表评分与一些dALFF和dfALFF指标相关。与HCs相比，ADHD患者左侧IPL与右侧小脑 Crus II之间的FC降低。以dALFF和dfALFF变异性为特征，我们获得了良好的曲线下面积和准确的分类。
本研究从动态局部脑活动的角度为ADHD相关的脑功能障碍提供了新的有价值的见解。对dALFF/dfALFF变异性的理解有助于理解神经生理机制，并可能有助于ADHD的诊断。
