Ali N M, Behnke J M, Manger B R
J Helminthol. 1985 Mar;59(1):83-93. doi: 10.1017/s0022149x00034532.
Experiments were carried out to define the haematological changes taking place during the first six weeks of a primary infection with Nematospiroides dubius. The general pattern of changes was observed to comprise a rapid increase in circulating leucocytes (4 to 5-fold increase) which consisted of a neutropl a, lymphocytosis, monocytosis and an eosinophilia. However, in strong responder NIH mice leucocyte counts returned to normal more rapidly than in other strains (by day 28). In contrast, in weak responder C57BL/10 mice the leucocyte counts whilst falling significantly relative to day 7 did not return to normal within the experimental period. Mice infected with irradiated larvae did not experience as high a leucocytosis as did mice given an identical number of normal larvae. The peak lymphocytosis, neutrophilia and monocytosis were all lower. The removal of adult worms from infected animals by treatment with pyrantel on days 9, 11, 13 and 16, also significantly altered the pattern of leucocytosis. The neutrophilia which was evident on day 7 returned rapidly to normal, whereas in mice which had retained their worms a peak neutrophilia was observed on day 14. These haematological changes were discussed and related to the failure of host-protective immunity to operate effectively during the early stages of a primary infection with N. dubius.
开展了实验以确定感染双睾旋尾线虫初次感染的前六周内发生的血液学变化。观察到变化的总体模式包括循环白细胞迅速增加（增加4至5倍），这由中性粒细胞增多、淋巴细胞增多、单核细胞增多和嗜酸性粒细胞增多组成。然而，在反应强烈的NIH小鼠中，白细胞计数比其他品系更快恢复正常（到第28天）。相比之下，在反应较弱的C57BL/10小鼠中，白细胞计数虽然相对于第7天显著下降，但在实验期内未恢复正常。感染辐照幼虫的小鼠没有经历与给予相同数量正常幼虫的小鼠一样高的白细胞增多症。淋巴细胞增多、中性粒细胞增多和单核细胞增多的峰值都较低。在第9、11、13和16天用噻嘧啶治疗感染动物以去除成虫，也显著改变了白细胞增多症的模式。第7天明显的中性粒细胞增多迅速恢复正常，而在保留蠕虫的小鼠中，在第14天观察到中性粒细胞增多的峰值。讨论了这些血液学变化，并将其与宿主保护性免疫在双睾旋尾线虫初次感染早期未能有效发挥作用相关联。
