Pierce Allison, Holden Marissa, Pham An, Lucidi Richard, New Erika P
Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia.
Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia; Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
J Pediatr Adolesc Gynecol. 2025 Aug;38(4):492-497. doi: 10.1016/j.jpag.2025.01.173. Epub 2025 Jan 31.
To determine if an educational handout regarding fertility preservation options affected rates of fertility preservation counseling, REI referrals, and gamete cryopreservation in transgender and nonbinary adolescents.
This was a retrospective observational pre/post intervention study of patients seen at a single academic gender-affirming care clinic and were prescribed gender-affirming hormone therapy from January 2022 to January 2023 and April 2023 to April 2024.
Educational handout.
The primary outcome was the rate of fertility preservation counseling.
There were 208 eligible patients, with 143 in the pre-intervention group and 65 in the post-intervention group. There was a significant increase in fertility preservation counseling rates after implementing the educational handout (31.5% counseling rate pre-intervention vs 58.46% post-intervention, percentage change 26.9%, SE 7.3%, P < .001). Of the patients counseled on fertility preservation, there was no significant difference in REI referral rates (percentage change -3.2%, SE 6.5%, P = .6208) or in gamete cryopreservation.
Increased access to educational materials increases the rate of fertility preservation counseling in transgender and nonbinary adolescents. More research is needed to determine how to improve resources and empower adolescents and their families to make informed decisions regarding reproductive health.
Clinicians who provide gender-affirming medical care should be equipped with educational resources they can offer their patients. Increased education and counseling may assist patients in making an informed decision regarding their fertility, regardless of whether or not they choose to preserve their fertility.
确定一份关于生育力保存选择的教育手册是否会影响跨性别和非二元青少年的生育力保存咨询率、生殖内分泌与不孕症（REI）转诊率以及配子冷冻保存情况。
这是一项在单一学术性性别肯定治疗诊所进行的回顾性观察性干预前后研究，研究对象为2022年1月至2023年1月以及2023年4月至2024年4月期间接受性别肯定激素治疗的患者。
教育手册。
主要结局是生育力保存咨询率。
共有208名符合条件的患者，干预前组有143人，干预后组有65人。实施教育手册后，生育力保存咨询率显著提高（干预前咨询率为31.5%，干预后为58.46%，百分比变化为26.9%，标准误为7.3%，P < .001）。在接受生育力保存咨询的患者中，REI转诊率（百分比变化为-3.2%，标准误为6.5%，P = .6208）或配子冷冻保存情况没有显著差异。
增加获取教育材料的机会可提高跨性别和非二元青少年的生育力保存咨询率。需要更多研究来确定如何改善资源，并使青少年及其家庭能够做出关于生殖健康的明智决策。
提供性别肯定医疗服务的临床医生应配备可供患者使用的教育资源。增加教育和咨询可能有助于患者就是否保存生育力做出明智决策，无论他们是否选择保存生育力。
