Noda Yoshihiro, Osawa Ryota, Takeda Yuya, Fujii Kyoshiro, Saijo Yuka, Kajiya Taku, Takeishi Kana, Moriyama Sotaro, Saeki Takashi, Nakajima Shinichiro, Kitahata Ryosuke
Shinjuku-Yoyogi Mental Lab Clinic, Tokyo, Japan; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Department of Psychiatry, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
Tokyo Yokohama TMS Clinic, Minato-Tokyo, Tokyo, Japan; Tokyo Yokohama TMS Clinic, Kosugi-Kanagawa, Kawasaki, Japan.
J Affect Disord. 2025 Apr 15;375:316-323. doi: 10.1016/j.jad.2025.01.131. Epub 2025 Jan 30.
Although approved for treatment in 2018, the effectiveness of intermittent theta-burst stimulation (iTBS) in a real-world setting remains inadequately studied. This observational study investigated the real-world use of iTBS, a usual medical practice for depression, factors influencing its effectiveness, and differences in effectiveness between 600 and 1200 pulses.
Data from patients who received iTBS therapy for depression at four private clinics between January 2021 and April 2024 were extracted. Patients were assessed using the 17-item Hamilton Depression Rating Scale at baseline and after treatment completion. Correlation and multiple regression analyses were performed to investigate clinico-demographic factors and stimulation parameters associated with iTBS effectiveness. Safety was assessed using all relevant data, and effectiveness was evaluated using eligible samples.
Among 538 patients meeting eligibility criteria for effectiveness evaluation (mean age 40.8 ± 13.8 years, 44.1 % women), 63 completed iTBS with 600 pulses, and 475 completed iTBS with 1200 pulses. Overall response and remission rates were 69.1 % and 53.7 %, respectively, with no significant difference in effectiveness between iTBS-600 and iTBS-1200. Multiple regression analysis indicated fewer depressive episodes (β = -0.103, t = -2.080, p = 0.038) and more treatment sessions (β = 0.134, t = 3.155, p = 0.002) may have contributed to the positive effect of iTBS therapy. The most common adverse event was stimulation site pain. No severe adverse events, such as seizure induction or manic switch, were observed.
The results suggest the highly favorable effectiveness of iTBS therapy for major depressive disorder in real-world settings.
