Li Chunhui, Wang Lei, Feng Dongmei, Bian Xiyun, You Hu, Liang Chengquan, Wang Jing
Department of Ophthalmology, Shanghai Health Medical Center, No. 67 Dajishan, Wuxi 214065, PR China.
Department of Ophthalmology, Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital Daoqian Campus), No. 26 Daoqian Street, Gusu District, Suzhou 215002, PR China.
Prim Care Diabetes. 2025 Apr;19(2):195-200. doi: 10.1016/j.pcd.2025.01.005. Epub 2025 Jan 31.
Diabetic retinopathy (DR) is a leading cause of vision impairment in type 2 diabetes. This study aims to clarify the association between baseline triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and DR risk in type 2 diabetes patients to aid in prevention and treatment strategies.
This retrospective cohort study included 1049 patients with type 2 diabetes who met the inclusion criteria and underwent health examinations at our hospital from January 2017 to December 2023. All patients completed seven follow-up visits within seven years. Baseline data from 2017 were utilized for the analysis. The Kaplan-Meier method and the Cox proportional hazards regression model and restricted cubic spline (RCS) method were employed to analyze the association between baseline serum TG/HDL-C ratio and the risk of DR.
A total of 1049 patients were included in the cohort, with a median follow-up period of seven years. During the follow-up period, 124 new cases of DR were identified, with an incidence rate of 11.8 %. The incidence of DR showed an upward trend with increasing baseline TG/HDL-C ratio. After adjusting for various potential confounding factors in the Cox proportional hazards regression model, high TG/HDL-C ratio levels were identified as a risk factor for DR (HR=3.04, 95 % CI 1.55-5.98, P = 0.0029).In the dose-response relationship analysis, a significant nonlinear relationship was observed between the TG/HDL-C ratio and the risk of diabetic retinopathy (DR) (nonlinear P value = 0.029). The risk of DR significantly increased when the TG/HDL-C ratio reached 3.3 (HR = 1.56, 95 % CI: 1.17-2.10, P = 0.003) and then leveled off.
High TG/HDL-C ratio is closely associated with the occurrence of DR and has a certain predictive value for the onset of DR.
The data that support the findings of this study are available from the corresponding author upon reasonable request. The data are not publicly available due to confidentiality agreements with the funding organization.
糖尿病视网膜病变（DR）是2型糖尿病患者视力损害的主要原因。本研究旨在阐明2型糖尿病患者基线甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值与DR风险之间的关联，以辅助预防和治疗策略。
这项回顾性队列研究纳入了1049例符合纳入标准且于2017年1月至2023年12月在我院接受健康检查的2型糖尿病患者。所有患者在7年内完成了7次随访。分析采用2017年的基线数据。采用Kaplan-Meier法、Cox比例风险回归模型和限制性立方样条（RCS）法分析基线血清TG/HDL-C比值与DR风险之间的关联。
队列共纳入1049例患者，中位随访期为7年。随访期间，共发现124例DR新发病例，发病率为11.8%。DR发病率随基线TG/HDL-C比值升高呈上升趋势。在Cox比例风险回归模型中对各种潜在混杂因素进行校正后，高TG/HDL-C比值水平被确定为DR的危险因素（HR=3.04，95%CI 1.55-5.98，P=0.0029）。在剂量反应关系分析中，观察到TG/HDL-C比值与糖尿病视网膜病变（DR）风险之间存在显著的非线性关系（非线性P值=0.029）。当TG/HDL-C比值达到3.3时，DR风险显著增加（HR=1.56，95%CI：1.17-2.10，P=0.003），然后趋于平稳。
高TG/HDL-C比值与DR的发生密切相关，对DR的发病具有一定的预测价值。
支持本研究结果的数据可在合理请求下从相应作者处获得。由于与资助机构的保密协议，这些数据不公开。
