Huang Chih-Wen, Wei Shu-Chen, Shieh Ming-Jium, Chou Jen-Wei, Chuang Chiao-Hsiung, Wang Horng-Yuan, Chang Chen-Wang, Wu Deng-Chyang, Huang Tien-Yu, Liu Yu-Hwa, Tsai Tzung-Jiun, Tai Wei-Chen, Tai Chi-Ming, Chung Chen-Shuan, Tsai Wen-Sy, Chang Chung-Hsin, Lin Ching-Pin, Lee Hsi-Chang, Chang Chun-Chao, Feng I-Che, Lin Chun-Chi, Cheng Mu-Liang, Yen Hsu-Heng
Division of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan.
Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
J Formos Med Assoc. 2025 Jan 31. doi: 10.1016/j.jfma.2025.01.018.
Despite industrialization and advances in healthcare, the prevalence of inflammatory bowel disease (IBD), which encompasses Crohn's disease (CD) and ulcerative colitis (UC), is increasing in Taiwan. Population-based studies can estimate the incidence or prevalence of IBD; however, there is a lack of information regarding the disease phenotype. Therefore, this study was designed to investigate the epidemiologic trends of IBD in Taiwan to gain a more comprehensive understanding.
Patient data were reviewed from a prospectively registered study by the Taiwan Society of IBD (TSIBD).
We collected data from 2752 patients with IBD, of whom 881 had CD and 1871 had UC. Their average age was 41.99 ± 15.19 years. The CD group had more male patients than the UC group (67.88% vs. 60.72%; p < .001). The rates of appendectomy, bowel resection, and surgery for perianal disease before IBD diagnosis, along with the increased use of steroids, immunomodulators, and biologics, were higher in the CD group. From 2005 to 2023, the ratio of UC to CD cases in Taiwan decreased, the proportions of patients with colonic and penetrating CD also declined, and the proportion of patients with UC exhibiting ulcerative proctitis increased.
In Taiwan, similar to high-income countries, the ratio of UC to CD cases has declined. The reduced of colonic and penetrating CD indicates that diagnostic awareness has improved and colonoscopic examination has become more comprehensive in Taiwan.
尽管实现了工业化且医疗保健取得了进步，但在台湾，包括克罗恩病（CD）和溃疡性结肠炎（UC）在内的炎症性肠病（IBD）的患病率仍在上升。基于人群的研究可以估计IBD的发病率或患病率；然而，关于疾病表型的信息却很匮乏。因此，本研究旨在调查台湾IBD的流行病学趋势，以获得更全面的了解。
回顾了台湾炎症性肠病学会（TSIBD）一项前瞻性注册研究中的患者数据。
我们收集了2752例IBD患者的数据，其中881例患有CD，1871例患有UC。他们的平均年龄为41.99±15.19岁。CD组男性患者多于UC组（67.88%对60.72%；p<0.001）。CD组在IBD诊断前的阑尾切除术、肠切除术和肛周疾病手术率，以及类固醇、免疫调节剂和生物制剂使用的增加率均更高。从2005年到2023年，台湾UC与CD病例的比例下降，结肠型和穿透型CD患者的比例也下降，而表现为溃疡性直肠炎的UC患者比例增加。
在台湾，与高收入国家类似，UC与CD病例的比例有所下降。结肠型和穿透型CD的减少表明台湾的诊断意识有所提高，结肠镜检查也更加全面。
