抗CD19嵌合抗原受体T细胞疗法在一名抗中性粒细胞胞浆抗体相关性血管炎治疗难治性患者的骨髓中诱导抗体血清转化并导致B细胞完全耗竭。 - Suppr

Anti-CD19 CAR T cell therapy induces antibody seroconversion and complete B cell depletion in the bone marrow of a therapy-refractory patient with ANCA-associated vasculitis.

作者信息

Minopoulou Ioanna, Wilhelm Artur, Albach Fredrik, Kleyer Arnd, Wiebe Edgar, Schallenberg Simon, Fleischmann Anja, Frick Mareike, Damm Frederik, Gogolok Julia, Serve Sebastian, Locher Benjamin Nick, Borie Dominic, Casteleyn Vincent, Biesen Robert, Dörner Thomas, Alexander Tobias, Zernicke Jan, Movassaghi Kamran, Hütter-Krönke Marie Luise, Schrezenmeier Eva, Schreiber Adrian, Schneider Udo, Bullinger Lars, Krönke Gerhard, Penack Olaf, Simon David

机构信息

Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.

出版信息

Ann Rheum Dis. 2025 Mar;84(3):e4-e7. doi: 10.1016/j.ard.2025.01.008. Epub 2025 Jan 31.

DOI:10.1016/j.ard.2025.01.008

PMID:39893102

Abstract

摘要

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Anti-CD19 CAR T cell therapy induces antibody seroconversion and complete B cell depletion in the bone marrow of a therapy-refractory patient with ANCA-associated vasculitis.

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