Yang Fangjun, Wang Huaming, Liu Miaomiao, Pei Shengtai, Qiu Xiaoming
Department of Orthopedic, Gansu Provincial Hospital of Traditional Chinese Medicine (The First Affiliated Hospital of Gansu University of Traditional Chinese Medicine), Lanzhou, 730050, China.
Gansu University of Traditional Chinese Medicine, Lanzhou, 730050, China.
Hereditas. 2025 Feb 1;162(1):14. doi: 10.1186/s41065-025-00373-z.
Previous observational studies have reported an association between chronic obstructive pulmonary disease (COPD) and osteoporosis (OP). The aim of this study is to investigate the causal relationship between COPD and OP by two-sample Mendelian randomization (MR) analysis. The current status of cross-sectional research between COPD and OP in the past decade was explored through bibliometrics.
Single nucleotide polymorphisms (SNPs) that have been found to be strongly associated with COPD were used as instrumental variables (IVs) in MR Analysis. The primary outcome of the study was BMD measurement at five specific anatomical sites, namely the whole body, femoral neck, lumbar spine, forearm, and heel. These BMD measurements were derived primarily from a genome-wide association study (GWAS) and summary statistics from the International Genetic Factors Consortium for Osteoporosis (GEFOS). The main analysis method was inverse variance weighting (IVW). Multiple sensitivity analyses were performed to assess the robustness and reliability of the current MR Results. Further confirmatory MR Analysis between COPD and OP was applied. In bibliometrics. Publications were extracted from the Web of Science core collection publications related to osteoporosis and sarcopenia published between January 2014 and October 2024; Bibliometrics and visualization were performed by Microsoft Office Excel, Citespace, and R (Bibliometrix).
The MR Findings suggest that there is no causal relationship between COPD and BMD at five specific anatomical sites. The results of the primary IVW MR Analysis were generally supported by our sensitivity MR Analysis. We performed MR Analysis for the validation of COPD and OP (IVW OR: 1.019; 95%CI: 0.898-1.564; p = 0.768) also did not support a causal relationship between COPD and BMD. A total of 471 articles written by 1119 organizations from 42 countries/regions by 3331 authors and published in 238 journals were identified in the bibliometric analysis. China is the leading country in terms of the number of publications. China Medical University contributed the most publications. The International Journal of Chronic Obstructive Pulmonary Disease has the highest publication in this field.
In conclusion, This MR Study found no causal relationship between COPD and OP, suggesting that the observed associations may be due to common genetic effects or environmental confounders. The global research trends in this field in the past decade were summarized through bibliometric analysis, and care became the focus of future research on the relationship between copd and OP.
既往观察性研究报告了慢性阻塞性肺疾病（COPD）与骨质疏松症（OP）之间存在关联。本研究旨在通过两样本孟德尔随机化（MR）分析探讨COPD与OP之间的因果关系。通过文献计量学方法探究过去十年中COPD与OP横断面研究的现状。
在MR分析中，将已发现与COPD密切相关的单核苷酸多态性（SNP）用作工具变量（IV）。本研究的主要结局是在五个特定解剖部位测量骨密度，即全身、股骨颈、腰椎、前臂和足跟。这些骨密度测量数据主要来自全基因组关联研究（GWAS）以及国际骨质疏松症遗传因素联盟（GEFOS）的汇总统计数据。主要分析方法是逆方差加权（IVW）。进行了多项敏感性分析以评估当前MR结果的稳健性和可靠性。对COPD与OP之间进行了进一步的验证性MR分析。在文献计量学方面，从2014年1月至2024年10月发表在Web of Science核心合集中与骨质疏松症和肌肉减少症相关的出版物中提取文献；通过Microsoft Office Excel、Citespace和R（Bibliometrix）进行文献计量学分析和可视化。
MR研究结果表明，COPD与五个特定解剖部位的骨密度之间不存在因果关系。主要IVW MR分析结果总体上得到了我们敏感性MR分析的支持。我们对COPD与OP进行的验证性MR分析（IVW OR：1.019；95%CI：0.898 - 1.564；p = 0.768）也不支持COPD与骨密度之间存在因果关系。在文献计量学分析中，共识别出由来自42个国家/地区的1119个组织的3331名作者撰写并发表在238种期刊上的471篇文章。中国是发表文章数量最多的国家。中国医科大学发表的文章数量最多。《国际慢性阻塞性肺疾病杂志》在该领域的发表量最高。
总之，本MR研究发现COPD与OP之间不存在因果关系，这表明观察到的关联可能是由于共同的遗传效应或环境混杂因素所致。通过文献计量学分析总结了过去十年该领域的全球研究趋势，护理成为未来COPD与OP关系研究的重点。
