Britt Hannah M, Robinson Carol V
Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3TA, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Oxford, OX1 3QU, UK.
Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3TA, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Oxford, OX1 3QU, UK.
Curr Opin Struct Biol. 2025 Apr;91:102993. doi: 10.1016/j.sbi.2025.102993. Epub 2025 Feb 1.
As health needs in our society evolve, the field of drug discovery must undergo constant innovation and improvement to identify novel targets and drug candidates. Owing to its ability to simultaneously capture biological interactions and provide in-depth molecular characterisation of the species involved, native mass spectrometry is starting to play an important role in this endeavour. Here, we discuss recent contributions that native mass spectrometry has made to drug discovery including deciphering protein-small molecule interactions, unravelling biochemical pathways, and integrating with complementary structural approaches.
