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困难胆囊中转开腹与腹腔镜胆囊次全切除术的长期疗效比较:一项单中心回顾性研究

Comparison of Long-Term Outcomes Between Conversion to Open and Laparoscopic Subtotal Cholecystectomy in the Difficult Gallbladder: A Single-Center Retrospective Study.

作者信息

Badve Shivani B, Turcotte Justin, Brennan Jane C, Klune John, Feather Cristina B, Rehrig Scott, Kulkarni Shreyus S

机构信息

Department of Surgery, Luminis Health, Annapolis, MD, USA.

出版信息

Am Surg. 2025 May;91(5):819-825. doi: 10.1177/00031348251318380. Epub 2025 Feb 2.

Abstract

BackgroundA difficult laparoscopic cholecystectomy (LC) confers an increased risk of bile duct injury. Traditionally, surgeons convert to open cholecystectomy (OC) as a bailout procedure for safer dissection. Laparoscopic subtotal cholecystectomy (LSC) has recently gained favor with comparable short-term complication rates, but differences in long-term outcomes remain unknown. We sought to compare long-term biliary outcomes between OC and LSC.Study DesignWe performed a single-center retrospective cohort study of adults who underwent non-elective LC converted to OC or LSC due to difficult dissection from 1/1/2015 to 12/31/2019. The primary outcome was a composite measure of postoperative biliary events, and we used time-to-event analysis to compare the 2 groups. We evaluated secondary outcomes using Chi-squared or independent t-tests as appropriate.ResultsOf 1089 patients who underwent non-elective LC, 68 (6%) underwent a bailout procedure (30 OC vs 38 LSC). There were no differences in demographics or comorbidities between the groups. Most patients (84%) had acute cholecystitis. Average follow-up times were 40 ∓ 29 months in OC and 54 ∓ 21 months in LSC. Biliary events occurred in 13 total patients (19%) with OC most commonly suffering bile leak (17%) and LSC most commonly having choledocholithiasis (11%). Kaplan-Meier analysis demonstrated no significant difference in biliary events between the groups ( = 0.71). Secondary outcomes were all similar between groups, except LSC had a shorter length of stay (2.9 ∓ 2.3 vs 5.1 ∓ 3.6 days, = 0.002).ConclusionsOC and LSC demonstrated comparable long-term biliary outcomes. In a difficult LC, surgeons may perform either bailout procedure to safely manage the gallbladder.

摘要

背景

困难的腹腔镜胆囊切除术(LC)会增加胆管损伤的风险。传统上,外科医生会转为开腹胆囊切除术(OC)作为一种更安全的挽救性手术以进行解剖。腹腔镜次全胆囊切除术(LSC)最近受到青睐,其短期并发症发生率相当,但长期结局的差异仍不明确。我们试图比较OC和LSC的长期胆道结局。

研究设计

我们对2015年1月1日至2019年12月31日期间因解剖困难而接受非选择性LC并转为OC或LSC的成年人进行了单中心回顾性队列研究。主要结局是术后胆道事件的综合指标,我们使用事件发生时间分析来比较两组。我们根据情况使用卡方检验或独立t检验评估次要结局。

结果

在1089例接受非选择性LC的患者中,68例(6%)接受了挽救性手术(30例OC vs 38例LSC)。两组在人口统计学或合并症方面无差异。大多数患者(84%)患有急性胆囊炎。OC组的平均随访时间为40±29个月,LSC组为54±21个月。共有13例患者(19%)发生胆道事件,OC组最常见的是胆漏(17%),LSC组最常见的是胆总管结石(11%)。Kaplan-Meier分析显示两组在胆道事件方面无显著差异(P = 0.71)。除LSC住院时间较短外(2.9±2.3天 vs 5.1±3.6天,P = 0.002),两组的次要结局均相似。

结论

OC和LSC显示出相当的长期胆道结局。在困难的LC手术中,外科医生可以选择任何一种挽救性手术来安全地处理胆囊。

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Laparoscopic subtotal cholecystectomy for severe cholecystitis.腹腔镜胆囊次全切除术治疗严重胆囊炎。
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