Bremner T A, Edwards K A
J Exp Zool. 1985 Apr;234(1):1-5. doi: 10.1002/jez.1402340102.
Development of Artemia salina embryos in the presence of ethidium bromide, an inhibitor of mitochondrial transcription, results in a dose dependent increase in the specific activity of lactate dehydrogenase, and a concomitant decrease in the specific activity of a cyanide-resistant superoxide dismutase. The inhibition of mitochondrial function by ethidium bromide appears to exert opposite effects on the nuclear cistrons encoding lactate dehydrogenase and superoxide dismutase, and suggests that a common mitochondrial signal may exert diametric effects on nuclear cistrons whose products are characteristic of alternate states of respiration.
在溴化乙锭（一种线粒体转录抑制剂）存在的情况下卤虫胚胎的发育，导致乳酸脱氢酶比活性呈剂量依赖性增加，同时抗氰超氧化物歧化酶比活性降低。溴化乙锭对线粒体功能的抑制似乎对编码乳酸脱氢酶和超氧化物歧化酶的核顺反子产生相反的影响，并表明一个共同的线粒体信号可能对其产物是呼吸交替状态特征的核顺反子产生截然相反的影响。
