Meng Linghui, Liu Shengyang, Luo Jinfeng, Tu Yanyi, Li Tao, Li Ping, Yu Jinzhuang, Shi Li
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, People's Republic of China.
Department of Allergy and Immunology, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
Redox Rep. 2025 Dec;30(1):2458942. doi: 10.1080/13510002.2025.2458942. Epub 2025 Feb 2.
Oxidative stress, characterized by an imbalance between excessive reactive oxygen species (ROS) production and impaired antioxidant defenses, is closely linked to the pathogenesis of various otorhinolaryngological disorders. Mitochondria, as the primary site of cellular energy production, play a crucial role in modulating oxidative stress. Mitochondrial dysfunction exacerbates ROS generation, leading to cellular damage and inflammatory responses. In otorhinolaryngological diseases, oxidative stress is strongly associated with conditions such as hearing loss, allergic rhinitis, and chronic sinusitis, where oxidative damage and tissue inflammation are key pathological features. Recent studies have highlighted the potential of antioxidant therapies to mitigate oxidative stress and restore homeostasis, offering promising avenues for alleviating symptoms in these diseases. However, despite the encouraging results from early-stage research, the clinical efficacy of antioxidant interventions remains to be fully established. This review provides an overview of the role of oxidative stress in otorhinolaryngological diseases and evaluates the therapeutic potential of antioxidant strategies.
氧化应激的特征是活性氧（ROS）产生过多与抗氧化防御受损之间的失衡，它与各种耳鼻喉科疾病的发病机制密切相关。线粒体作为细胞能量产生的主要场所，在调节氧化应激中起着至关重要的作用。线粒体功能障碍会加剧ROS的产生，导致细胞损伤和炎症反应。在耳鼻喉科疾病中，氧化应激与听力损失、过敏性鼻炎和慢性鼻窦炎等病症密切相关，其中氧化损伤和组织炎症是关键的病理特征。最近的研究强调了抗氧化疗法减轻氧化应激和恢复体内平衡的潜力，为缓解这些疾病的症状提供了有前景的途径。然而，尽管早期研究取得了令人鼓舞的结果，但抗氧化干预的临床疗效仍有待充分确立。本综述概述了氧化应激在耳鼻喉科疾病中的作用，并评估了抗氧化策略的治疗潜力。
