通过全基因组测序确定非结核分枝杆菌的医疗传播途径：一项系统综述
Identifying healthcare transmission routes of nontuberculous mycobacteria with whole genome sequencing: a systematic review.
作者信息
Schrank Spencer D, Gozum Dale Z, Martin Elise M, Snyder Graham M
机构信息
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Infection Prevention and Control, UPMC Presbyterian/Shadyside, Pittsburgh, PA, USA.
出版信息
Infect Control Hosp Epidemiol. 2025 Feb 3;46(4):1-6. doi: 10.1017/ice.2025.6.
OBJECTIVE
To enumerate and describe the effect of whole genome sequencing (WGS) on epidemiological investigations of healthcare-associated transmission of nontuberculous mycobacteria (NTM).
DESIGN
Systematic review.
METHODS
We performed a literature search using targeted search terms to identify articles meeting inclusion criteria. Data extraction of study characteristics and outcomes was performed by two independent researchers. The primary outcome was the author interpretation of WGS utility in the investigation of suspected healthcare-associated transmission of NTM. The secondary outcome was whether a transmission route was identified through WGS.
RESULTS
Thirty-one studies were included in the final analysis with 28 (90%) concluding that WGS was helpful in transmission investigations and in 19 of these 28 (68%) WGS aided in identifying a transmission route. The most common identified transmission routes were water-borne point sources (10), heater-cooler units (6), patient-to-patient (4), and a healthcare worker (1).
CONCLUSION
WGS is an informative tool in investigating healthcare transmission of NTM.
目的
列举并描述全基因组测序（WGS）对非结核分枝杆菌（NTM）医疗相关传播的流行病学调查的影响。
设计
系统评价。
方法
我们使用目标检索词进行文献检索，以识别符合纳入标准的文章。由两名独立研究人员对研究特征和结果进行数据提取。主要结果是作者对WGS在疑似NTM医疗相关传播调查中的效用的解读。次要结果是是否通过WGS确定了传播途径。
结果
最终分析纳入了31项研究，其中28项（90%）得出结论，WGS有助于传播调查，在这28项研究中的19项（68%）中，WGS有助于确定传播途径。最常见的确定传播途径是水源性点源（10例）、加热-冷却装置（6例）、患者-to-患者（4例）和一名医护人员（1例）。
结论
WGS是调查NTM医疗传播的一种信息丰富的工具。
Zotero 插件