Moore Bethany J, Willcox Darren
Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Org Lett. 2025 Feb 14;27(6):1402-1406. doi: 10.1021/acs.orglett.4c04717. Epub 2025 Feb 2.
-Dichlorocyclopropanes are important structural moieties in a range of industrial sectors and have been the focus of considerable interest within the synthetic community over the years. Synthetic methodologies to access -dichlorocyclopropanes, however, remain limited. To address this challenge, we report the development of new dichloromethyl(diaryl) sulfonium salts as reagents for the -dichlorocyclopropanation of electron-rich olefins via a free dichlorocarbene pathway under mild conditions in yields of up to 70%. This methodology provides access to previously unreported -dichlorocyclopropanes.
-二氯环丙烷是一系列工业领域中的重要结构部分，多年来一直是合成领域相当受关注的焦点。然而，用于制备-二氯环丙烷的合成方法仍然有限。为应对这一挑战，我们报道了新型二氯甲基（二芳基）锍盐的开发，该盐可作为试剂，用于在温和条件下通过游离二氯卡宾途径对富电子烯烃进行-二氯环丙烷化反应，产率高达70%。该方法能够制备出此前未报道过的-二氯环丙烷。
