Berggren U
J Neural Transm. 1985;61(3-4):175-81. doi: 10.1007/BF01251911.
The effect of a single i.p. injection of lithium chloride on brain monoamine synthesis and tyrosine and tryptophan levels in brain and plasma in rats was studied. Acute lithium administration was found to decrease brain tyrosine levels, which most likely was due to decreased plasma tyrosine levels. Brain tryptophan levels were mainly unaffected whereas plasma tryptophan leves were slightly decreased at 8 hours after lithium administration. Brain catecholamine synthesis was decreased at 4 hours and increased at 48 hours after the injection of lithium. Brain 5-hydroxytryptamine (5-HT) synthesis was decreased at all time intervals after the injection of lithium. It is concluded that the effects of acute lithium administration on brain monoamine synthesis are not mainly due to its effect on brain tyrosine and tryptophan levels in rats. Furthermore acute lithium administration appears to affect 5-HT synthesis to a greater extent than it affects catecholamine synthesis.
研究了腹腔注射一次氯化锂对大鼠脑单胺合成以及脑和血浆中酪氨酸和色氨酸水平的影响。发现急性给予锂会降低脑酪氨酸水平，这很可能是由于血浆酪氨酸水平降低所致。脑色氨酸水平基本未受影响，而在给予锂后8小时血浆色氨酸水平略有下降。注射锂后4小时脑儿茶酚胺合成减少，48小时增加。注射锂后的所有时间间隔脑5-羟色胺（5-HT）合成均减少。得出结论，急性给予锂对大鼠脑单胺合成的影响主要不是由于其对脑酪氨酸和色氨酸水平的影响。此外，急性给予锂似乎对5-HT合成的影响比对儿茶酚胺合成的影响更大。
