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鸟嘌呤脱氨酶在小鼠脑中的分布。

Distribution of guanine deaminase in mouse brain.

作者信息

Berger S J, Carter J G, Lowry O H

出版信息

J Neurochem. 1985 Jun;44(6):1736-40. doi: 10.1111/j.1471-4159.1985.tb07162.x.

DOI:10.1111/j.1471-4159.1985.tb07162.x
PMID:3989559
Abstract

Guanine deaminase was measured in nearly 100 different areas of mouse brain. The levels are relatively high in all parts of the telencephalon, both gray and white. It is especially active in parts of the olfactory tubercle and amygdala. Levels in the diencephalon range from low to as high as in the telencephalon. Brain areas caudal to the diencephalon, including all parts of the cerebellum, are almost uniformly below the level of detection. The enzyme is also virtually absent from the retina. The extreme range of concentration suggests that guanine deaminase might play a role in the metabolism of a neuroeffector.

摘要

在小鼠大脑近100个不同区域测量了鸟嘌呤脱氨酶。端脑的所有部分,无论是灰质还是白质,该酶水平都相对较高。它在嗅结节和杏仁核的部分区域特别活跃。间脑的水平从低到与端脑一样高。间脑尾部的脑区,包括小脑的所有部分,几乎都低于检测水平。视网膜中实际上也没有这种酶。浓度的极大差异表明鸟嘌呤脱氨酶可能在神经效应器的代谢中起作用。

相似文献

1
Distribution of guanine deaminase in mouse brain.鸟嘌呤脱氨酶在小鼠脑中的分布。
J Neurochem. 1985 Jun;44(6):1736-40. doi: 10.1111/j.1471-4159.1985.tb07162.x.
2
[Determination of the disulfide groups in pig brain guanases].[猪脑鸟嘌呤酶中二硫键基团的测定]
Boll Soc Ital Biol Sper. 1977 Dec 15;53(23):2199-203.
3
[Liver and brain guinea-pig guanine aminohydrolase (author's transl)].[肝脏和脑豚鼠鸟嘌呤氨基水解酶(作者译)]
Rev Esp Fisiol. 1978 Jun;34(2):205-12.
4
BRAIN GUANINE DEAMINASE: PURIFICATION, PROPERTIES AND REGIONAL DISTRIBUTION.脑鸟嘌呤脱氨酶:纯化、性质及区域分布
Biochim Biophys Acta. 1963 Oct 1;77:307-17. doi: 10.1016/0006-3002(63)90501-8.
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The histochemical demonstration of guanase: observations in the human central nervous system.鸟嘌呤酶的组织化学显示:在人类中枢神经系统中的观察
Acta Histochem. 1979;64(2):187-93. doi: 10.1016/S0065-1281(79)80072-0.
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[Immunohistochemical stain of guanase using direct labelling antibody].[使用直接标记抗体的鸟嘌呤酶免疫组织化学染色]
Nihon Shokakibyo Gakkai Zasshi. 1988 Jan;85(1):42-7.
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[One-step determination of guanase activity].[鸟嘌呤酶活性的一步测定法]
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QUANTITATIVE COMPARISONS OF BRAIN STRUCTURES FROM INSECTIVORES TO PRIMATES.从食虫目动物到灵长类动物脑结构的定量比较
Am Zool. 1964 Feb;4:59-74. doi: 10.1093/icb/4.1.59.
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Histochemical mapping of ATPase and 5'-nucleotidase in the telencephalon and diencephalon of mouse.小鼠端脑和间脑中ATP酶和5'-核苷酸酶的组织化学定位
J Hirnforsch. 1984;25(5):511-26.
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Absence of guanine deaminase from cerebellum.小脑缺乏鸟嘌呤脱氨酶。
Neurology. 1970 Apr;20(4):383.

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Biochemical Characterization of Adenine Deaminase and Guanine Deaminase and Their Potential Application in Lowering Purine Content in Beer.腺嘌呤脱氨酶和鸟嘌呤脱氨酶的生化特性及其在降低啤酒中嘌呤含量的潜在应用
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Concentration of nucleosides and related compounds in cerebral and cerebellar cortical areas and white matter of the human brain.
人脑大脑皮质、小脑皮质区域及白质中核苷及相关化合物的浓度
Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):833-44. doi: 10.1007/s10571-006-9103-3. Epub 2006 Aug 1.