Lee Pureun-Haneul, An Min-Hyeok, Jang An-Soo
Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Allergy Asthma Immunol Res. 2025 Jan;17(1):22-31. doi: 10.4168/aair.2025.17.1.22.
Angiogenesis is an important event in the development of allergic inflammation as well as in the pathophysiology of tissue remodeling in asthma. Increased angiogenesis is a well-documented feature of airway remodeling in asthma. Angiogenesis refers to the formation of new blood vessels from pre-existing endothelium. Angiogenesis can be initiated by endogenous angiogenic factors released from mesenchymal cells or inflammatory cells. Under physiological conditions, angiogenesis is controlled by an equilibrium between pro-endogenous and anti-endogenous angiogenic factors released from the extracellular matrix to become bioavailable. The presence of increased size and number of bronchial blood vessels indicates that angiogenesis plays a crucial role in tissue growth and remodeling in asthma. However, the diagnostic significance of circulating angiogenic factors in asthma remains unclear. This review summarizes the role of angiogenesis in airway remodeling in asthma, and the potential diagnostic implications of circulating angiogenetic factors.
血管生成是变应性炎症发展以及哮喘组织重塑病理生理学中的一个重要事件。血管生成增加是哮喘气道重塑的一个有充分文献记载的特征。血管生成是指从预先存在的内皮细胞形成新的血管。血管生成可由间充质细胞或炎症细胞释放的内源性血管生成因子启动。在生理条件下，血管生成由细胞外基质释放的促内源性和抗内源性血管生成因子之间的平衡控制，以使其具有生物活性。支气管血管大小和数量增加表明血管生成在哮喘组织生长和重塑中起关键作用。然而，循环血管生成因子在哮喘中的诊断意义仍不清楚。本综述总结了血管生成在哮喘气道重塑中的作用以及循环血管生成因子的潜在诊断意义。
