Li Zhanbin, Yao Zhenyu, Liu Qiaoran
Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Key Laboratory of Metabolism and Gastrointestinal Tumor, the First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.
Front Nutr. 2025 Jan 17;12:1458764. doi: 10.3389/fnut.2025.1458764. eCollection 2025.
The correlation between white cell count and metabolically healthy obesity (MHO) remains elusive among obese American adults. This study endeavors to elucidate this association.
This study enrolled 6,580 obese patients from the National Health and Nutrition Examination Survey (NHANES). Obesity phenotypes were defined by presence/absence of metabolic syndrome components. Weighted multivariate logistic regression analyses were used to assess the association between white cell count and MHO occurrence. Restricted cubic spline analysis characterized dose-response relationships, and stratified analyses explored these relationships across sociodemographic and lifestyle factors.
In this study, MHO prevalence is 11.9% among obese adults. The risk of MHO was inversely correlated with WBC [OR (95%): 0.81 (0.76, 0.86), < 0.001], lymphocytes [OR (95%): 0.56 (0.47, 0.68), < 0.001], monocytes [OR (95%): 0.41 (0.22, 0.75), = 0.004], and neutrophils count [OR (95%): 0.82 (0.76, 0.88), < 0.001]. WBC and neutrophils showed L-shaped associations, while lymphocytes, monocytes, and RBCs had linear patterns. Furthermore, stratified analyses demonstrated blood cell counts consistently predicted MHO risk across subgroups.
In this study, we provide novel insights into the association between blood cell count and the presence of MHO among obese individuals. Blood cell count is an accessible biomarker for dynamically tracking the presence of MHO.
在美国肥胖成年人中，白细胞计数与代谢健康型肥胖（MHO）之间的相关性仍不明确。本研究旨在阐明这种关联。
本研究纳入了来自美国国家健康与营养检查调查（NHANES）的6580名肥胖患者。肥胖表型由代谢综合征成分的存在与否来定义。采用加权多变量逻辑回归分析来评估白细胞计数与MHO发生之间的关联。受限立方样条分析表征剂量反应关系，分层分析则探讨了这些关系在社会人口统计学和生活方式因素中的情况。
在本研究中，肥胖成年人中MHO的患病率为11.9%。MHO的风险与白细胞[比值比（95%）：0.81（0.76，0.86），<0.001]、淋巴细胞[比值比（95%）：0.56（0.47，0.68），<0.001]、单核细胞[比值比（95%）：0.41（0.22，0.75），=0.004]和中性粒细胞计数[比值比（95%）：0.82（0.76，0.88），<0.001]呈负相关。白细胞和中性粒细胞呈现L形关联，而淋巴细胞、单核细胞和红细胞呈线性模式。此外，分层分析表明血细胞计数在各亚组中均能一致地预测MHO风险。
在本研究中，我们对血细胞计数与肥胖个体中MHO存在之间的关联提供了新的见解。血细胞计数是动态追踪MHO存在情况的一个可获取的生物标志物。
