Bi Taiyu, Duan Xiaotian, Yin Yipeng
Thoracic Surgery, First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China.
Nursing Apartment, First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China.
Front Cardiovasc Med. 2025 Jan 17;11:1498914. doi: 10.3389/fcvm.2024.1498914. eCollection 2024.
Takayasu's arteritis (TA) is an autoimmune disease that invades large arteries and mostly occurs in women of childbearing age. It leads to thickening and loss of elasticity of the arterial wall, and eventually vascular occlusion, aneurysm or dissection formation. Type B aortic dissection (TBAD) during pregnancy is a rare disease, which is mostly caused by the increase of blood volume in circulation during pregnancy, the effect of estrogen and progesterone on the aorta, or congenital diseases. TBAD in TA pregnant women is very rare, and the condition is often complicated. It is necessary to make a multidisciplinary treatment plan and determine the timing and method of operation to save the life of mother and fetus.
We report a pregnant woman at 35 weeks of gestation who presented to the emergency department with sudden and continuously unrelieved chest pain. She had TA for five years. Thoracoabdominal aortic computed tomography with angiography (CTA) showed acute TBAD. Her blood pressure was 209/73 mmHg and could not be lowered with Urapidil, therefore she was diagnosed with complex Stanford type B aortic dissection. She underwent cesarean section under general anesthesia, and the tracheal tube was not removed after surgery. Thoracic endovascular aortic repair (TEVAR) was administered under anesthesia 8 h after cesarean section. Intraoperative aortography showed that the stent blocked the tear of the intima of the aorta, and the false cavity was reduced. Her blood pressure was reduced to the normal range (140/90 mmHg or less), and the baby's vital signs were stable. They were discharged five days later. Use steroids to control TA throughout treatment. One year after the operation, the mother was healthy and the baby developed well.
Early identification and accurate diagnosis should be made for acute TBAD in late pregnancy. Under the premise of stable hemodynamics, the fetus is delivered by cesarean section first and then TEVAR is the preferred treatment. The diagnosis and treatment plan of AD during pregnancy should be developed and implemented by multiple disciplines according to the vital signs of mother and fetus. TA pregnant women should take steroids during pregnancy, closely detect inflammatory indicators, and avoid pathogenic microbial infection, inflammatory state and complications. At the same time, the necessary follow-up is also the key to ensure the treatment effect.
大动脉炎(TA)是一种侵袭大动脉的自身免疫性疾病,多见于育龄女性。它会导致动脉壁增厚和弹性丧失,最终导致血管闭塞、动脉瘤或夹层形成。妊娠期B型主动脉夹层(TBAD)是一种罕见疾病,主要由妊娠期循环血容量增加、雌激素和孕激素对主动脉的影响或先天性疾病引起。TA孕妇发生TBAD非常罕见,且病情常较复杂。需要制定多学科治疗方案并确定手术时机和方法,以挽救母婴生命。
我们报告一名孕35周的孕妇,因突发持续性胸痛就诊于急诊科。她患TA已五年。胸腹部主动脉计算机断层血管造影(CTA)显示为急性TBAD。她的血压为209/73 mmHg,使用乌拉地尔无法降低,因此被诊断为复杂Stanford B型主动脉夹层。她在全身麻醉下接受了剖宫产手术,术后未拔除气管导管。剖宫产术后8 h在麻醉下进行了胸主动脉腔内修复术(TEVAR)。术中主动脉造影显示支架封堵了主动脉内膜撕裂口,假腔缩小。她的血压降至正常范围(140/90 mmHg及以下),婴儿生命体征稳定。五天后出院。整个治疗过程中使用类固醇控制TA。术后一年,母亲身体健康,婴儿发育良好。
对于妊娠晚期急性TBAD应尽早识别并准确诊断。在血流动力学稳定的前提下,先剖宫产娩出胎儿,然后TEVAR是首选治疗方法。妊娠期主动脉夹层的诊断和治疗方案应多学科根据母婴生命体征制定并实施。TA孕妇孕期应服用类固醇,密切监测炎症指标,避免病原微生物感染、炎症状态及并发症。同时,必要的随访也是确保治疗效果的关键。