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Dantrolene as a Potential Strategy to Prevent Doxorubicin-Induced Cardiotoxicity: Mechanistic Promise and Clinical Prospects.

作者信息

Braga Dias Itamar, Maass Alexander H

机构信息

University of Groningen, University Medical Center Groningen, Department of Experimental Cardiology, Groningen, the Netherlands.

出版信息

JACC CardioOncol. 2025 Jan 21;7(1):53-55. doi: 10.1016/j.jaccao.2024.12.002. eCollection 2025 Jan.

DOI:10.1016/j.jaccao.2024.12.002
PMID:39896124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11782010/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acac/11782010/99a09802f8fc/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acac/11782010/56a7ba3dec57/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acac/11782010/99a09802f8fc/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acac/11782010/56a7ba3dec57/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acac/11782010/99a09802f8fc/gr1.jpg

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本文引用的文献

1
Effect of resistance exercise on physical fitness, quality of life, and fatigue in patients with cancer: a systematic review.抗阻运动对癌症患者体能、生活质量及疲劳的影响：一项系统评价
Front Oncol. 2024 Jul 19;14:1393902. doi: 10.3389/fonc.2024.1393902. eCollection 2024.
2
Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells.运动通过调节 B 细胞抑制阿霉素诱导的心脏毒性。
Circ Res. 2024 Mar;134(5):550-568. doi: 10.1161/CIRCRESAHA.123.323346. Epub 2024 Feb 7.
3
Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model.
在乳腺癌模型中，丹曲林可减轻阿霉素的心脏毒性，而不降低其抗肿瘤疗效。
Transl Oncol. 2020 Feb;13(2):471-480. doi: 10.1016/j.tranon.2019.12.006. Epub 2020 Jan 7.
4
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.人诱导多能干细胞衍生的心肌细胞重现了乳腺癌患者对阿霉素诱导的心脏毒性的易感性。
Nat Med. 2016 May;22(5):547-56. doi: 10.1038/nm.4087. Epub 2016 Apr 18.
5
Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia.疾病机制：心力衰竭和致命性心律失常中的兰尼碱受体缺陷
Nat Clin Pract Cardiovasc Med. 2006 Jan;3(1):43-52. doi: 10.1038/ncpcardio0419.
6
Regulation of calcium release by interdomain interaction within ryanodine receptors.通过兰尼碱受体结构域间相互作用对钙释放的调节。
Front Biosci. 2002 Mar 1;7:d671-83. doi: 10.2741/A803.
7
Female sex and higher drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer.女性性别和较高药物剂量作为儿童癌症多柔比星治疗晚期心脏毒性作用的危险因素。
N Engl J Med. 1995 Jun 29;332(26):1738-43. doi: 10.1056/NEJM199506293322602.