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木村病中的嗜酸性粒细胞ETosis及夏科-莱登结晶

Eosinophil ETosis and Charcot-Leyden crystals in Kimura disease.

作者信息

Inoue Yuzaburo, Ogata Hitoshi, Sato Yoshitake, Kato Daigo, Mitsunaga Kanako, Saito Mamiko, Ishigaki Tatsuya, Tomiita Minako, Kuraishi Hiroshi, Ito Keisuke, Ueki Shigeharu

机构信息

Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan.

Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan.

出版信息

J Allergy Clin Immunol Glob. 2024 Dec 25;4(2):100397. doi: 10.1016/j.jacig.2024.100397. eCollection 2025 May.

DOI:10.1016/j.jacig.2024.100397
PMID:39896211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11783097/
Abstract

Two cases of refractory Kimura disease that required treatment with biologic agents are reported. Their pathology suggests the involvement of eosinophil ETosis, which is active cell death producing Charcot-Leyden crystals.

摘要

报告了两例需要使用生物制剂治疗的难治性木村病病例。其病理显示嗜酸性粒细胞胞吐作用参与其中，这是一种产生夏科-莱登结晶的活性细胞死亡过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/11783097/e65ce06f7559/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/11783097/9460437dc817/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/11783097/e65ce06f7559/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/11783097/9460437dc817/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/11783097/e65ce06f7559/gr2.jpg

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本文引用的文献

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Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification.单细胞蛋白质组学和转录组学捕获嗜酸性粒细胞的发育，并确定 IL-5 在其谱系过渡扩增中的作用。
Immunity. 2024 Jul 9;57(7):1549-1566.e8. doi: 10.1016/j.immuni.2024.04.027. Epub 2024 May 21.
2
Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG-related disease and Kimura disease.两种不同纤维化疾病（IgG 相关疾病和 Kimura 病）中存在具有独特疾病特征的滤泡辅助性 T 细胞群体。
J Allergy Clin Immunol. 2022 Aug;150(2):440-455.e17. doi: 10.1016/j.jaci.2022.03.034. Epub 2022 May 11.
3
Eosinophil ETosis-Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis.
嗜酸性粒细胞 ETosis 介导的嗜酸性粒细胞性肉芽肿伴多血管炎中半乳糖凝集素-10 的释放。
Arthritis Rheumatol. 2021 Sep;73(9):1683-1693. doi: 10.1002/art.41727. Epub 2021 Aug 11.
4
Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation.嗜酸性粒细胞炎症中的夏科-莱登结晶：活性细胞溶解导致结晶形成。
Curr Allergy Asthma Rep. 2019 Jun 15;19(8):35. doi: 10.1007/s11882-019-0868-0.
5
Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death.夏科-莱登结晶的形成与嗜酸性粒细胞细胞外陷阱细胞死亡密切相关。
Blood. 2018 Nov 15;132(20):2183-2187. doi: 10.1182/blood-2018-04-842260. Epub 2018 Aug 28.
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