Effect of Resmetirom or Placebo in NASH Fibrosis Patients With <5% or >5% Weight Loss and/or on Baseline GLP-1 Therapy in the MAESTRO-NASH 52-Week Serial Liver Biopsy Study.
出版信息
Gastroenterol Hepatol (N Y). 2024 Dec;20(12 Suppl 11):8-9.
Abstract
摘要
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本文引用的文献
1
A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis.一项评估 Resmetirom 治疗伴有肝纤维化的 NASH 的 3 期随机对照试验。
N Engl J Med. 2024 Feb 8;390(6):497-509. doi: 10.1056/NEJMoa2309000.
2
Design of the phase 3 MAESTRO clinical program to evaluate resmetirom for the treatment of nonalcoholic steatohepatitis.用于评估resmetirom治疗非酒精性脂肪性肝炎的3期MAESTRO临床项目设计
Aliment Pharmacol Ther. 2024 Jan;59(1):51-63. doi: 10.1111/apt.17734. Epub 2023 Oct 2.
3
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.2-[3,5-二氯-4-(5-异丙基-6-氧代-1,6-二氢哒嗪-3-基氧基)苯基]-3,5-二氧代-2,3,4,5-四氢[1,2,4]三嗪-6-腈（MGL-3196）的发现，一种在治疗血脂异常的临床试验中具有高度选择性的甲状腺激素受体β激动剂。
J Med Chem. 2014 May 22;57(10):3912-23. doi: 10.1021/jm4019299. Epub 2014 Apr 8.
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