Warren Christopher M, Xu Xueyan S, Jackson Mark, McKinney Walter G, Wu John Z, Welcome Daniel E, Waugh Stacey, Chapman Phillip, Sinsel Erik W, Service Samantha, Krajnak Kristine, Dong Ren G
Physical Effects Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA.
Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA.
Vibration. 2024;7(3):722-737. doi: 10.3390/vibration7030038.
Over-exposure of the hand-arm system to intense vibration and force over time may cause degeneration of the vascular, neurological, and musculoskeletal systems in the fingers. A novel animal model using rat tails has been developed to understand the health effects on human fingers exposed to vibration and force when operating powered hand tools or workpieces. The biodynamic responses, such as vibration stress, strain, and power absorption density, of the rat tails can be used to help evaluate the health effects related to vibration and force and to establish a dose-effect relationship. While the biodynamic responses of cadaver rat tails have been investigated, the objective of the current study was to determine whether the biodynamic responses of living rat tails are different from those of cadaver rat tails, and whether the biodynamic responses of both living and cadaver tails change with exposure duration. To make direct comparisons, the responses of both cadaver and living rat tails were examined on four different testing stations. The transfer function of each tail under a given contact force (2 N) was measured at each frequency in the one-third octave bands from 20 to 1000 Hz, and used to calculate the mechanical system parameters of the tails. The transfer functions were also measured at different exposure durations to determine the time dependency of the response. Differences were observed in the vibration biodynamic responses between living and cadaver tails, but the general trends were similar. The biodynamic responses of both cadaver and living rat tails varied with exposure duration.
随着时间的推移，手部 - 手臂系统过度暴露于强烈振动和力下，可能会导致手指的血管、神经和肌肉骨骼系统退化。一种使用大鼠尾巴的新型动物模型已被开发出来，以了解在操作电动手动工具或工件时，暴露于振动和力下对人类手指的健康影响。大鼠尾巴的生物动力学响应，如振动应力、应变和功率吸收密度，可用于帮助评估与振动和力相关的健康影响，并建立剂量 - 效应关系。虽然已经对大鼠尸体尾巴的生物动力学响应进行了研究，但本研究的目的是确定活体大鼠尾巴的生物动力学响应是否与尸体尾巴不同，以及活体和尸体尾巴的生物动力学响应是否随暴露持续时间而变化。为了进行直接比较，在四个不同的测试站检查了尸体和活体大鼠尾巴的响应。在20至1000Hz的1/3倍频程频段内的每个频率下，测量了每条尾巴在给定接触力（2N）下的传递函数，并用于计算尾巴的机械系统参数。还在不同的暴露持续时间下测量传递函数，以确定响应的时间依赖性。观察到活体和尸体尾巴在振动生物动力学响应方面存在差异，但总体趋势相似。尸体和活体大鼠尾巴的生物动力学响应均随暴露持续时间而变化。
