Characteristics and risk factors for infection and mortality caused by in patients with acute pancreatitis.

BACKGROUND

The purpose of this study is to investigate the risk factors for carbapenem-resistant (CRKP) infection and death of infections in acute pancreatitis (AP) patients.

METHODS

This was a retrospective analysis of AP patients with infection between January 2019 and April 2024. Logistic regression model was used to determine the risk factors for acquisition of CRKP. Cox proportional hazards regression model was used to identify risk factors for mortality of infection.

RESULTS

A total of 113 AP patients experienced infections, including 66 with CRKP infection and 47 with CSKP infection. The mortality rate of these patients was 36.3%, with a significantly higher mortality rate in the CRKP group than in the CSKP group ( < 0.001). Only mechanical ventilation (OR = 2.301; 95% CI 1.02-5.20; = 0.045) was the independent risk factor for CRKP infection in patients with AP. Surgery (HR 0.38; 95% CI 0.20-0.75; = 0.005) and mechanical ventilation (HR 2.93; 95% CI 1.10-7.82; = 0.032) were the independent risk factors associated with mortality of infection in patients with AP.

CONCLUSION

infection has become a threat to patients with AP. Therefore, implementing preventive and control measures based on risk factors is crucial for the prognosis.