Abdulrahim Ahmed, Sabri Ahmed, Teruya Bryan, Li Changzhao, Cantu David
Pathology, Creighton University School of Medicine, Omaha, USA.
Pathology, University of Nebraska Medical Center, Omaha, USA.
Cureus. 2025 Jan 1;17(1):e76758. doi: 10.7759/cureus.76758. eCollection 2025 Jan.
Large B-cell lymphoma (LBCL) with interferon regulatory factor 4 (IRF4) rearrangement is characterized by the monotonous proliferation of medium- to large-sized cells with strong expression of IRF4/multiple myeloma oncogene 1 (MUM1). It predominantly affects children and young adults with a median age of 12. The reported disease sites include head and neck lymph nodes, the Waldeyer's ring, and the gastrointestinal tract. Here, we report two cases of LBCL with IRF4 rearrangement in 73-year-old and 71-year-old patients. The first patient presented with a lung nodule, while the second patient presented with right palatine tonsillitis. To our knowledge, LBCL with IRF4 rearrangement involving the lung in an elderly patient has not been previously reported.
伴有干扰素调节因子4（IRF4）重排的大B细胞淋巴瘤（LBCL）的特征是中等至大细胞的单一性增殖，并伴有IRF4/多发性骨髓瘤癌基因1（MUM1）的强表达。它主要影响儿童和年轻人，中位年龄为12岁。报告的疾病部位包括头颈部淋巴结、咽淋巴环和胃肠道。在此，我们报告了两例分别为73岁和71岁患者的伴有IRF4重排的LBCL病例。首例患者表现为肺结节，而第二例患者表现为右侧腭扁桃体炎。据我们所知，此前尚未有老年患者伴有IRF4重排的LBCL累及肺部的报道。
