刚果民主共和国布卡武孕妇中[具体物种名称1]、[具体物种名称2]、[具体物种名称3]和[具体物种名称4]的流行情况及临床相关性

Prevalence and clinical correlates of spp., , and in pregnant women in Bukavu, Democratic Republic of the Congo.

作者信息

Himschoot Lisa, Mulinganya Guy, Rogier Tess, Bisimwa Ghislain, Kampara Freddy, Kujirakwinja Yvette, Mongane Jules, Mubalama Innocent, Callens Steven, Vaneechoutte Mario, Cools Piet

机构信息

Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Faculty of Medicine, Catholic University of Bukavu, Bukavu, Democratic Republic of Congo.

出版信息

Front Cell Infect Microbiol. 2025 Jan 17;14:1514884. doi: 10.3389/fcimb.2024.1514884. eCollection 2024.

BACKGROUND

is a key pathogen in bacterial vaginosis (BV), but the role of the different species remains unclear. We investigated the role of four species, as well as , and in BV.

METHODS

From 331 pregnant women from the Democratic Republic of the Congo, BV was diagnosed using Nugent scoring and a cervicovaginal lavage was used to quantify , , , by qPCR. Univariate associations between these species and clinical outcomes were assessed. A logistic regression model and ROC curves were calculated to determine the best diagnostic marker for BV.

RESULTS

Here, (75.8%) was the most prevalent species and (36.0%) the most common species. All investigated spp. were prevalent (50.9-57.9%) in women with (asymptomatic) BV. Univariate analysis revealed no significant associations with clinical symptoms of BV, while (positive Whiff test, high pH), (high pH) and (low pH) were associated with signs of BV. was associated with markers of urinary tract infection. Women with had higher odds of delivering preterm. ROC analyses showed that was the best marker for BV (AUC 0.81), and the combined model further increased the diagnostic performance (AUC 0.90).

CONCLUSION

All species were involved in BV, although none were associated with the most important clinical symptoms of BV and none emerged as a superior molecular marker for BV.

背景

是细菌性阴道病（BV）的关键病原体，但不同物种的作用仍不清楚。我们研究了四种物种以及、和在BV中的作用。

方法

从刚果民主共和国的331名孕妇中，使用 Nugent评分诊断BV，并使用宫颈阴道灌洗通过qPCR对、、、进行定量。评估这些物种与临床结果之间的单变量关联。计算逻辑回归模型和ROC曲线以确定BV的最佳诊断标志物。

结果

在此，（75.8%）是最普遍的物种，（36.0%）是最常见的物种。所有研究的物种在患有（无症状）BV的女性中都很普遍（50.9 - 57.9%）。单变量分析显示与BV的临床症状无显著关联，而（阳性胺试验、高pH值）、（高pH值）和（低pH值）与BV的体征相关。与尿路感染标志物相关。患有的女性早产几率更高。ROC分析表明是BV的最佳标志物（AUC 0.81），联合模型进一步提高了诊断性能（AUC 0.90）。