Fan Yuncao, Chen Wei, Lin Wenhui, Jin Jungu, Lou Enyu, Lao Jiaying, Chen Yu-Hsin, Shao Jianzhi, Wang Qizeng, Jiang Qingxi, Wang Fan, Xu Jinzhong, Liu Yanlong, Yang Bo
Department of Cardiovascular Medicine, Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, China.
School of Public Health, Wenzhou Medical University, Wenzhou, China.
Front Nutr. 2025 Jan 17;11:1521124. doi: 10.3389/fnut.2024.1521124. eCollection 2024.
Increased consumption of fish has beneficial impacts upon emotional health; however, this benefit for comorbid depressive symptoms and coronary heart disease (DCHD) is not fully clear. We aimed to investigate the relationship between consumption of marine fish and DCHD in Chinese adults.
A cross-sectional study was conducted in 1,106 participants aged 25-95 years living in Taizhou, China. Fish intakes were assessed by using a validated food frequency questionnaire, with their tertiles as category levels of ≤1 time/week, 2-6 times/week, and ≥7 times/week. Coronary heart disease (CHD) was diagnosed using the coronary angiography, while the concurrent depressive symptoms was indicated using ≥8 scores from hospital anxiety and depression scales (HADS). Primary measurements were the prevalent DCHD, presented as multivariate-adjusted odds ratios (ORs) with 95% confidence intervals (CIs).
A total of 932 participants were included, 88 (9.44%) participants with depressive symptoms, 477 (51.18%) CHD, and 106 (11.37%) DCHD, respectively. Participants at the highest tertile of fish intake have a lower odds of DCHD compared with those at the lowest (OR: 0.34, 95% CI: 0.20, 0.58), with 42% reductions in odds of DCHD for per one-tertile (3 times/week) increase (OR: 0.58, 95% CI: 0.45, 0.76). The beneficial associations were pronounced with decreased odds of depressive symptom (OR: 0.31, 95% CI: 0.20, 0.47), but not with CHD (OR: 0.87, 95% CI: 0.59, 1.29).
Increased consumption of marine fish is associated with decreased severity of depressive symptoms, which might have great benefits toward comorbid depressive symptom and with coronary heart diseases.
鱼类消费量的增加对情绪健康有有益影响；然而，这种对合并抑郁症状和冠心病（DCHD）的益处尚不完全清楚。我们旨在研究中国成年人中食用海鱼与DCHD之间的关系。
对居住在中国台州的1106名年龄在25 - 95岁的参与者进行了一项横断面研究。通过使用经过验证的食物频率问卷评估鱼类摄入量，将其三等分位数作为分类水平，即每周≤1次、每周2 - 6次和每周≥7次。使用冠状动脉造影诊断冠心病，同时使用医院焦虑和抑郁量表（HADS）≥8分来表示并发的抑郁症状。主要测量指标是普遍存在的DCHD，以多变量调整后的优势比（OR）和95%置信区间（CI）表示。
总共纳入了932名参与者，分别有88名（9.44%）有抑郁症状，477名（51.18%）有冠心病，106名（11.37%）有DCHD。与鱼类摄入量最低三分位数的参与者相比，最高三分位数的参与者患DCHD的几率更低（OR：0.34，95% CI：0.20，0.58），每增加一个三分位数（每周3次），DCHD的几率降低42%（OR：0.58，95% CI：0.45，0.76）。有益关联在抑郁症状几率降低方面显著（OR：0.31，95% CI：0.20，0.47），但在冠心病方面不显著（OR：0.87，95% CI：0.59，1.29）。
海鱼消费量的增加与抑郁症状严重程度的降低有关，这可能对合并抑郁症状和冠心病有很大益处。
