Morshead Mackenzie L, Tanguay Robyn L
Sinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University 28645 East Highway 34, Corvallis, OR 97331, USA.
Curr Opin Toxicol. 2025 Mar;41. doi: 10.1016/j.cotox.2024.100516. Epub 2024 Dec 24.
The rapid assessment of chemical hazards to human health, with reduced reliance on mammalian testing, is essential in the 21st century. Early life stage zebrafish have emerged as a leading model in the field due to their amenability to high throughput developmental toxicity testing while retaining the benefits of using a whole vertebrate organism with high homology with humans. Zebrafish are particularly well suited for a variety of study areas that are more challenging in other vertebrate model systems including microbiome work, transgenerational studies, gene-environment interactions, molecular responses, and mechanisms of action. The high volume of data generated from zebrafish screening studies is highly valuable for QSAR modeling and dose modeling for use in predictive hazard assessment. Recent advancements and challenges in using early life stage zebrafish for predictive human toxicology are reviewed.
在21世纪，减少对哺乳动物试验的依赖，快速评估化学物质对人类健康的危害至关重要。早期幼体斑马鱼已成为该领域的主要模型，因为它们适合进行高通量发育毒性测试，同时保留了使用与人类具有高度同源性的完整脊椎动物的优势。斑马鱼特别适合多种在其他脊椎动物模型系统中更具挑战性的研究领域，包括微生物组研究、跨代研究、基因-环境相互作用、分子反应和作用机制。斑马鱼筛选研究产生的大量数据对于用于预测性危害评估的定量构效关系（QSAR）建模和剂量建模非常有价值。本文综述了使用早期幼体斑马鱼进行预测性人类毒理学研究的最新进展和挑战。
