Buzdar Zulfiqar Ali, Ali Hamza, Munir Maria, Shad Naveed A, Rakha Allah, Munawar Anam
Department of Forensic Medicine/Medical Jurisprudence, University of Health Sciences, Lahore, Pakistan.
Forensic Medicine and Toxicology Department, Sahara Medical College, Narowal, Pakistan.
Heliyon. 2025 Jan 11;11(2):e41864. doi: 10.1016/j.heliyon.2025.e41864. eCollection 2025 Jan 30.
In the domain of criminal investigations, the integration of nanotechnology has emerged as a transformative force, mirroring advancements across diverse scientific realms. This study focuses on leveraging the synergistic potential of a bimetallic TiO2/Bi2O3 nano-composite to meticulously evaluate vitreous potassium levels in human cadavers. The designed TiO2/Bi2O3 nano-composite exhibits a finely structured morphology, characterized by diminutive sheet-like formations spanning the nano-scale dimension of 20-250 nm. Through rigorous analysis, we establish a robust linear correlation (R = 0.992) between the nanocomposite and potassium concentrations in postmortem vitreous samples. Notably, the nano-composite demonstrates an exceptional limit of detection at 0.001 nM, surpassing comparable materials and methodologies reported to date (FTIR, GC-MS and biochemical analysis) and provide measurement of time since death with a precision of 1 h. The elevated sensitivity of the nano-composite to potassium concentrations opens new possibilities for enhancing the accuracy and efficiency of forensic analyses, ultimately aiding in the pursuit of justice.
在刑事调查领域，纳米技术的整合已成为一股变革力量，反映了不同科学领域的进步。本研究着重利用双金属TiO₂/Bi₂O₃纳米复合材料的协同潜力，以精确评估人类尸体玻璃体液中的钾含量。所设计的TiO₂/Bi₂O₃纳米复合材料呈现出精细的结构形态，其特征是具有跨越20 - 250纳米纳米尺度的微小片状结构。通过严格分析，我们在纳米复合材料与死后玻璃体液样本中的钾浓度之间建立了稳健的线性相关性（R = 0.992）。值得注意的是，该纳米复合材料在0.001 nM时表现出出色的检测限，超过了迄今报道的同类材料和方法（傅里叶变换红外光谱法、气相色谱 - 质谱联用仪和生化分析），并能以1小时的精度测定死亡时间。纳米复合材料对钾浓度的高灵敏度为提高法医分析的准确性和效率开辟了新的可能性，最终有助于司法的推进。
