Shukla R, Shukla S B
J Vet Pharmacol Ther. 1985 Mar;8(1):71-5. doi: 10.1111/j.1365-2885.1985.tb00926.x.
Chloralose anaesthesia in dogs increased the H+ ion concentration significantly from its reference values. The findings favoured that it was most probably engendered through anaesthetic depression of neural centre regulating H+ ion concentration of blood. Such increase was largely contributed by a significant increase in its metabolic fraction. A further increase of metabolic fraction after separate and joint section of carotid sinus nerves and vagi indicated their holding effect. The section of carotid sinus nerve induced greater increase in this fraction than that of vagi. It indicated differences between the two nerves in their metabolic fraction controlling influence. Hyperpnoea after vagi section decreased the carbonic acid fraction, whereas marginally reduced ventilation after carotid sinus nerve section increased the carbonic acid fraction. Moreover, the overall changes in H+ ion concentration followed the changes in carbonic acid fraction. The present study suggested that the depressive effect of chloralose anaesthesia on H+ ion controlling neural mechanism could be largely determined by degree of increase in its metabolic fraction.
水合氯醛麻醉犬可使氢离子浓度较其参考值显著升高。研究结果表明，这很可能是由于麻醉对调节血液氢离子浓度的神经中枢产生抑制作用所致。这种升高在很大程度上是由其代谢部分的显著增加所导致。在分别切断和联合切断颈动脉窦神经和迷走神经后，代谢部分进一步增加，表明它们具有维持作用。切断颈动脉窦神经后该部分的增加幅度大于切断迷走神经后。这表明两条神经在控制代谢部分的影响方面存在差异。切断迷走神经后的呼吸急促降低了碳酸部分，而切断颈动脉窦神经后通气量略有减少则增加了碳酸部分。此外，氢离子浓度的总体变化与碳酸部分的变化一致。本研究表明，水合氯醛麻醉对氢离子控制神经机制的抑制作用在很大程度上可能取决于其代谢部分的增加程度。
