Wintjens Marieke S J N, Aydeniz Eda, van Rosmalen Frank, Driessen Rob G H, Hulshof Anne-Marije, Bergmans Dennis C J J, van Kuijk Sander M J, van der Horst Iwan C C, van Bussel Bas C T
Department of Intensive Care Medicine, Maastricht University Medical Centre +, Maastricht, The Netherlands.
Department of Clinical Epidemiology and Technology Assessment, Maastricht University Medical Centre +, Maastricht, The Netherlands.
Crit Care Explor. 2025 Feb 3;7(2):e1211. doi: 10.1097/CCE.0000000000001211. eCollection 2025 Feb 1.
A review of the study processes and protocols afterward by the researchers themselves is scarce.
The present study aimed to evaluate the study design and the process of data collection of the Maastricht Intensive Care COVID (MaastrICCht) cohort during the COVID-19 pandemic. This evaluation provides information about the quality of the predefined questions and contributes to transparency in science.
DESIGN, SETTING, AND PARTICIPANTS: Critical appraisal of studies using data from the MaastrICCht cohort.
Evaluation of the process of study design and data collection during the COVID-19 pandemic, focusing on the research process and results.
From March 2020 to April 2023, all patients diagnosed with COVID-19 admitted to the ICU at Maastricht University Medical Center + (n = 544) were included in the MaastrICCht cohort. In total, 37 studies were carried out until April 2024. Fifteen studies addressed 11 of the 13 predetermined research questions, whereas 22 additional studies were performed based on the initial research questions described in the design. Furthermore, 10 studies were conducted with other researchers in national and international collaboration as a response to new arising questions based on evidence that appeared relevant during the pandemic.
Our critical appraisal indicated that using a study protocol enabled many publications and (inter)national collaborations, although formulating pertinent research questions in the context of a novel disease appeared daunting. Despite this, most questions were successfully addressed, whereas few were resolved by other researchers or lost importance due to the expanding body of knowledge.
研究人员事后对研究过程和方案进行回顾的情况很少见。
本研究旨在评估新冠疫情期间马斯特里赫特重症监护新冠（MaastrICCht）队列的研究设计和数据收集过程。该评估提供了有关预定义问题质量的信息，并有助于提高科学的透明度。
设计、背景和参与者：使用MaastrICCht队列数据对研究进行批判性评价。
评估新冠疫情期间的研究设计和数据收集过程，重点关注研究过程和结果。
2020年3月至2023年4月，所有在马斯特里赫特大学医学中心+确诊感染新冠并入住重症监护病房的患者（n = 544）被纳入MaastrICCht队列。截至2024年4月，共开展了37项研究。15项研究涉及13个预定研究问题中的11个，另外22项研究是基于设计中描述的初始研究问题进行的。此外，针对疫情期间出现的相关证据引发的新问题，有10项研究是与其他国家和国际研究人员合作开展的。
我们的批判性评价表明，使用研究方案促成了许多出版物以及（国际）合作，尽管在一种新型疾病的背景下提出相关研究问题似乎具有挑战性。尽管如此，大多数问题都得到了成功解决，只有少数问题由其他研究人员解决或因知识体系的不断扩大而失去重要性。
