Chimura T, Morisaki N
Jpn J Antibiot. 1985 Jan;38(1):69-73.
The endocervical flora was examined in 20 with rupture of membranes, 20 pregnant women served as control. The isolated organisms were aerobic and anaerobic in both groups, whereas P. cepacia was common in group of rupture of membranes, but another microorganisms were not statistically significant. Culture specimens taken from the vagina in nonpregnant women showed a higher presence of total bacteria than did those in pregnant women. The MICs of ampicillin (ABPC) were measured against isolated aerobic organisms from rupture of membranes. The distribution of sensitivity of Bacillus sp. was 0.20 microgram/ml, but another organisms were inhibited in concentration of higher than 3.13 micrograms/ml. The antibacterial effect of amniotic fluid during 24 weeks of gestation on S. aureus and S. pyogenes, but during 34 to 39 weeks of gestation the amniotic fluid has inhibitory effect only on the growth of K. pneumoniae. In contrast, the growth of E. coli was not inhibited by amniotic fluid during 24 to 39 weeks of gestation.
对20例胎膜破裂患者的宫颈内菌群进行了检查，并以20例孕妇作为对照。两组分离出的微生物均有需氧菌和厌氧菌，而洋葱伯克霍尔德菌在胎膜破裂组中较为常见，但其他微生物无统计学差异。非孕妇阴道培养标本显示，其总细菌数量高于孕妇。测定了氨苄西林（ABPC）对胎膜破裂分离出的需氧菌的最低抑菌浓度（MIC）。芽孢杆菌属的敏感分布为0.20微克/毫升，但其他微生物在浓度高于3.13微克/毫升时受到抑制。妊娠24周时羊水对金黄色葡萄球菌和化脓性链球菌有抗菌作用，但在妊娠34至39周时，羊水仅对肺炎克雷伯菌的生长有抑制作用。相比之下，在妊娠24至39周期间，羊水对大肠杆菌的生长无抑制作用。
