Kasapoglu Dilek Ezgi, Tekin Kemal, Cankurtaran Veysel, Dogan Serdar, Dirican Emre
Department of Ophthalmology, Mustafa Kemal University, Hatay, Turkey.
Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Clin Exp Optom. 2025 Feb 3:1-6. doi: 10.1080/08164622.2025.2461233.
Since inflammation plays an important role in the pathogenesis of diabetic retinopathy, serum biomarkers and retinal imaging aimed at evaluating the presence of inflammation have emerged as useful tools to monitor the appearance and progression of diabetic retinopathy.
This study aims to investigate the value of YKL-40 levels in patients with diabetes mellitus with different stages of diabetic retinopathy and without diabetic retinopathy, and to compare those findings with results from healthy individuals without diabetes mellitus.
This prospective cross-sectional study included 67 diabetic patients with or without diabetic retinopathy who underwent cataract surgery and 23 patients (control group) having no ocular and systemic disease other than senile cataract. Participants with diabetes mellitus were separated into three subgroups: the first group consisted of 26 patients without diabetic retinopathy, the second group included 21 patients with non-proliferative diabetic retinopathy and the third group included 20 patients with proliferative diabetic retinopathy. Serum and aqueous humour YKL-40 levels were analysed and compared between the groups.
The mean serum ( < 0.001) and aqueous humour ( < 0.001) YKL-40 levels were statistically significantly lower in control subjects compared to patients with diabetes mellitus. The aqueous humour YKL-40 levels showed statistically significant elevations with the progression of diabetic retinopathy. Duration of diabetes mellitus was significantly correlated with aqueous humour YKL-40 levels ( = 0.001, = 0.384).
Both serum and aqueous humour YKL-40 levels are higher in patients with diabetes mellitus compared to healthy subjects. Levels of YKL-40 in aqueous humour increase with the progression of diabetic retinopathy.
由于炎症在糖尿病视网膜病变的发病机制中起重要作用，旨在评估炎症存在的血清生物标志物和视网膜成像已成为监测糖尿病视网膜病变的出现和进展的有用工具。
本研究旨在调查不同阶段糖尿病视网膜病变和无糖尿病视网膜病变的糖尿病患者中YKL-40水平的价值，并将这些结果与无糖尿病的健康个体的结果进行比较。
这项前瞻性横断面研究包括67例接受白内障手术的糖尿病性视网膜病变患者和无糖尿病性视网膜病变的糖尿病患者，以及23例（对照组）除老年性白内障外无眼部和全身疾病的患者。糖尿病患者分为三个亚组：第一组由26例无糖尿病视网膜病变的患者组成，第二组包括21例非增殖性糖尿病视网膜病变患者，第三组包括20例增殖性糖尿病视网膜病变患者。分析并比较各组之间的血清和房水YKL-40水平。
与糖尿病患者相比，对照组的平均血清（<0.001）和房水（<0.001）YKL-40水平在统计学上显著降低。随着糖尿病视网膜病变的进展，房水YKL-40水平显示出统计学上的显著升高。糖尿病病程与房水YKL-40水平显著相关（=0.001，=0.384）。
与健康受试者相比，糖尿病患者的血清和房水YKL-40水平均较高。房水中YKL-40水平随糖尿病视网膜病变的进展而升高。
