Kambayashi J, Ohshiro T, Mori T, Kosaki G
Jpn J Surg. 1985 Jan;15(1):75-80. doi: 10.1007/BF02469862.
To elucidate the etiology of hemostatic abnormalities in cases of obstructive jaundice, we occluded the bile duct of rats for one week and found that the moderately jaundiced rats exhibited a marked reduction in the value of Hepaplastin test and Thrombotest with minimum histological changes in liver. All other coagulation and fibrinolysis profiles were within normal limits. These findings exclude the occurrence of a hypercoagulable state or hypofibrinolytic state in the jaundiced rats due to bile duct occlusion. Similar results were obtained in rats with tube choledochostomy. The abnormalities were almost completely prevented by the daily parenteral administration of vitamin K. These observations suggest that malabsorption of vitamin K may be the sole etiologic factor producing hemostatic defects in case of uncomplicated obstructive jaundice.
为阐明梗阻性黄疸病例中止血异常的病因，我们将大鼠胆管闭塞一周，发现中度黄疸的大鼠肝促凝血酶原激酶试验和凝血酶试验值显著降低，而肝脏组织学变化最小。所有其他凝血和纤维蛋白溶解指标均在正常范围内。这些发现排除了胆管闭塞导致黄疸大鼠出现高凝状态或低纤维蛋白溶解状态的可能性。在胆总管造口术的大鼠中也得到了类似结果。每日经胃肠外给予维生素K几乎完全预防了这些异常。这些观察结果表明，维生素K吸收不良可能是单纯性梗阻性黄疸病例中产生止血缺陷的唯一病因。
