Derosiere Gerard, Shokur Solaiman, Vassiliadis Pierre
Lyon Neuroscience Research Center, Impact team, INSERM U1028 - CNRS UMR5292, Lyon 1 University, Bron, France.
Translational Neural Engineering Laboratory, Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Nat Commun. 2025 Feb 3;16(1):1307. doi: 10.1038/s41467-024-55016-0.
Over the past decade, research has shown that the primary motor cortex (M1), the brain's main output for movement, also responds to rewards. These reward signals may shape motor output in its final stages, influencing movement invigoration and motor learning. In this Perspective, we highlight the functional roles of M1 reward signals and propose how they could guide advances in neurotechnologies for movement restoration, specifically brain-computer interfaces and non-invasive brain stimulation. Understanding M1 reward signals may open new avenues for enhancing motor control and rehabilitation.
在过去十年中，研究表明，作为大脑运动主要输出的初级运动皮层（M1）也对奖励做出反应。这些奖励信号可能在运动的最后阶段塑造运动输出，影响运动活力和运动学习。在这篇观点文章中，我们强调了M1奖励信号的功能作用，并提出它们如何能够为运动恢复的神经技术进步提供指导，特别是脑机接口和非侵入性脑刺激。了解M1奖励信号可能为增强运动控制和康复开辟新途径。
