Zhang Zixuan, Xing Yuying, Gong Tingdan, Li Wanlin, Zhang Siwei, Wei Lanlan
National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Front Cell Infect Microbiol. 2025 Jan 20;14:1428491. doi: 10.3389/fcimb.2024.1428491. eCollection 2024.
Co-infection with human immunodeficiency virus (HIV) significantly increases the incidence of human papillomavirus (HPV) infection and HPV-related cancers among men who have sex with men (MSM). Conversely, HPV infection can also influence HIV acquisition rates. HIV-induced immune suppression may affect chromosomal stability, gene expression, protein function and other molecular components in MSM with HPV-related cancers. Additionally, HIV infection also alters cellular mechanisms by compromising immune responses and epithelial integrity. In this review, we reviewed the influence of HIV on specific HPV-related cancers in MSM, including oropharyngeal squamous cell carcinoma, penile cancer, and anal cancer. We integrated epidemiological data from the past five years and discussed diagnosis and treatment strategies. Overall, our review offers crucial insights into the underlying molecular and cellular mechanisms of these co-infection MSM patients. Our review aims to assist future research in developing effective treatment strategies for MSM with HIV/HPV co-infection.
人类免疫缺陷病毒（HIV）合并感染显著增加了男男性行为者（MSM）中人类乳头瘤病毒（HPV）感染及HPV相关癌症的发病率。相反，HPV感染也会影响HIV的感染率。HIV引起的免疫抑制可能会影响MSM中与HPV相关癌症患者的染色体稳定性、基因表达、蛋白质功能及其他分子成分。此外，HIV感染还会通过损害免疫反应和上皮完整性来改变细胞机制。在本综述中，我们回顾了HIV对MSM中特定HPV相关癌症的影响，包括口咽鳞状细胞癌、阴茎癌和肛门癌。我们整合了过去五年的流行病学数据，并讨论了诊断和治疗策略。总体而言，我们的综述为这些合并感染的MSM患者潜在的分子和细胞机制提供了关键见解。我们的综述旨在帮助未来的研究为HIV/HPV合并感染的MSM制定有效的治疗策略。
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