Department of Pathology, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Cancer Centre Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands.
Department of Pathology, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Cancer Centre Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands.
Trends Mol Med. 2024 Sep;30(9):890-902. doi: 10.1016/j.molmed.2024.05.009. Epub 2024 Jun 9.
Countless efforts have been made to eradicate cervical cancer worldwide, including improving disease screening and human papillomavirus (HPV) vaccination programs. Nevertheless, cervical cancer still claims the lives of more than 300 000 women every year. Persistent infections with high-risk HPV genotypes 16 and 18 are the main cause of cancer and may result in HPV integration into the host genome. The central dogma is that HPV integration is an important step in oncogenesis, but in fact, it impedes the virus from replicating and spreading. HPV causing cervical cancer can therefore be perceived as a failed evolutionary viral trait. Here we outline the occurrence and mechanisms of HPV integration and how this process results in oncogenic transformation.
全世界已经做出了无数努力来消除宫颈癌，包括改善疾病筛查和人乳头瘤病毒（HPV）疫苗接种计划。然而，每年仍有超过 30 万名妇女死于宫颈癌。高危型 HPV 基因型 16 和 18 的持续感染是癌症的主要原因，并可能导致 HPV 整合到宿主基因组中。中心法则认为 HPV 整合是致癌过程中的重要步骤，但实际上，它会阻碍病毒的复制和传播。因此，导致宫颈癌的 HPV 可以被视为一种失败的进化病毒特征。在这里，我们概述了 HPV 整合的发生和机制，以及这一过程如何导致致癌转化。
