Lingaraj Jayanthi, Prabhu Shankar D, Parameswaran Anantanarayanan, Srinivasa Prasad T
Meenakshi Cleft and Craniofacial Centre, Chennai, Tamil Nadu India.
Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu India.
J Maxillofac Oral Surg. 2025 Feb;24(1):293-300. doi: 10.1007/s12663-024-02155-y. Epub 2024 Mar 31.
The aim was to evaluate the clinical efficacy of intra-nasal vitamin B12 spray compared to oral B12 in the recovery of transient neurosensory disturbances of the lingual nerve post-mandibular third molar surgery.
Thirty patients, who experienced paresthesia of the tongue a day after mandibular third molar surgery, participated in this study. They were randomly divided into two groups: Group 1 (intra-nasal vitamin B12 spray) and Group 2 (oral vitamin B12). Clinical neurosensory tests were conducted at various intervals, and the Fisher's exact test was performed for group comparisons based on recovery.
Out of the 30 patients (18 females and 12 males) with transient lingual neurosensory disturbances, after third molar extraction, 15 used the intra-nasal vitamin B12 spray, while the other 15 took oral vitamin B12 tablets. Significant recovery was observed in the nasal group compared to the oral group at POD 16 (p = 0.005) and POD 24 (p = 0.003)."
Intra-nasal vitamin B12 sprays were found to be conducive adjuvants to treat transient neurosensory disturbances following third molar surgery. Further studies on its routine application post-neurosensory complications are recommended.
旨在评估鼻内使用维生素B12喷雾剂与口服维生素B12相比，在下颌第三磨牙手术后舌神经短暂性神经感觉障碍恢复中的临床疗效。
30例在下颌第三磨牙手术后一天出现舌感觉异常的患者参与了本研究。他们被随机分为两组：第1组（鼻内使用维生素B12喷雾剂）和第2组（口服维生素B12）。在不同时间间隔进行临床神经感觉测试，并基于恢复情况进行组间比较的Fisher精确检验。
在30例（18例女性和12例男性）下颌第三磨牙拔除后出现短暂性舌神经感觉障碍的患者中，15例使用鼻内维生素B12喷雾剂，另外15例口服维生素B12片。与口服组相比，在术后第16天（p = 0.005）和第24天（p = 0.003）观察到鼻内组有显著恢复。
发现鼻内维生素B12喷雾剂是治疗第三磨牙手术后短暂性神经感觉障碍的有益辅助药物。建议对其在神经感觉并发症后的常规应用进行进一步研究。
