Jonas Jost B, Panda-Jonas Songhomitra, Mehta Jodhbir S, Jonas Rahul A
Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France.
Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):8. doi: 10.1167/iovs.66.2.8.
The purpose of this study was to examine anatomic relationships between Descemet's membrane (DM) and neighboring tissues.
Human eyes enucleated due to malignant uveal melanoma were histomorphometrically examined.
In all 50 eyes included in the study (age = 59.2 ± 13.3 years), a cellular tissue (mean thickness at the DM end = 14.2 ± 19.5 µm), originating in the transitional zone, extended into the space between the peripheral DM and corneal stroma for a length of 142 ± 71 µm. This length decreased with the longer part of the DM covered with Hassall-Henle-bodies (beta = -0.30, B = -0.28, 95% confidence interval [CI] = -0.54 to -0.03, P = 0.03) and was not related with age (P = 0.84), axial length (P = 0.94), transitional zone length (P = 0.51), and the DM-scleral spur distance (P = 0.72). The DM thinned toward its end and the DM-like components appeared getting together and merging with transitional zone tissue fibers. The transitional zone length (mean = 267 ± 115 µm) varied from 82 µm to 586 µm, increased with longer DM-scleral spur distance (beta = 0.80, B = 0.67, 95% CI = 0.52 to 0.82, P < 0.001), and was not related with axial length (P = 0.74) or age (P = 0.18). The DM-scleral spur distance (mean = 660 ± 136 µm, range = 302 µm-979 µm) was not related with axial length (P = 0.60) or age (P = 0.06). The scleral spur dimensions (basis = 193 ± 103 µm, height = 151 ± 46 µm, length = 231 ± 75 µm) were not related with the DM-scleral spur distance (all P > 0.35), axial length (all P > 0.07), and age (all P > 0.25). In all eyes, the scleral spur tip was orientated anteriorly, with the longitudinal ciliary muscle inserting at its posterior side.
DM is firmly connected with the transitional zone tissue, and indirectly through the corneoscleral TM, with the scleral spur. With the latter connected through the longitudinal ciliary muscle and Bruch's membrane with the optic disc, the DM is part of an anatomic spherical unit of the globe.
本研究旨在探讨后弹力层（DM）与邻近组织之间的解剖关系。
对因恶性葡萄膜黑色素瘤而摘除的人眼进行组织形态计量学检查。
在本研究纳入的所有50只眼中（年龄=59.2±13.3岁），一种起源于过渡区的细胞组织（在DM末端的平均厚度=14.2±19.5μm）延伸至周边DM与角膜基质之间的间隙，长度为142±71μm。该长度随着被哈氏小体覆盖的DM较长部分而减小（β=-0.30，B=-0.28，95%置信区间[CI]=-0.54至-0.03，P=0.03），且与年龄（P=0.84）、眼轴长度（P=0.94）、过渡区长度（P=0.51）以及DM-巩膜突距离（P=0.72）无关。DM向其末端变薄，且类似DM 的成分似乎聚集并与过渡区组织纤维融合。过渡区长度（平均=267±115μm）范围为82μm至586μm，随着DM-巩膜突距离的增加而增加（β=0.80，B=0.67，95%CI=0.52至0.82，P<0.001），且与眼轴长度（P=0.74）或年龄（P=0.18）无关。DM-巩膜突距离（平均=660±136μm，范围=302μm - 979μm）与眼轴长度（P=0.60）或年龄（P=0.06）无关。巩膜突尺寸（基部=193±103μm，高度=151±46μm，长度=231±75μm）与DM-巩膜突距离（所有P>0.35）、眼轴长度（所有P>0.07）以及年龄（所有P>0.25）均无关。在所有眼中，巩膜突尖端向前，纵行睫状肌插入其后侧。
DM与过渡区组织牢固相连，并通过角膜巩膜小梁网间接与巩膜突相连。由于后者通过纵行睫状肌和 Bruch 膜与视盘相连，DM 是眼球解剖球形单元的一部分。
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