Cioni Paul, Chretien Pascale, Goulvestre Claire, Ballot Eric, Khelifi-Touhami Dounia, Mariette Xavier, Nocturne Gaëtane
Rhumatologie, CHU Bicêtre, Le Kremlin-Bicetre, Île-de-France, France.
Laboratoire d'Immunologie, CHU Bicêtre, Le Kremlin-Bicetre, Île-de-France, France.
RMD Open. 2025 Feb 4;11(1):e005212. doi: 10.1136/rmdopen-2024-005212.
Anti-SS-B antibodies are often associated with anti-SS-A in Sjögren's disease. Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. We aimed to evaluate the prevalence and diagnostic significance of isolated anti-SS-B antibodies.
We conducted a retrospective study across three hospitals of the Assistance Publique-Hôpitaux de Paris. Patients with anti-SS-B positivity were identified using ELISA, addressable laser beam immunoassay (ALBIA) and immunodot assays. They were retained if anti-SS-B was positive in two techniques and anti-SS-A was absent. Clinical, biological and immunological data were extracted and presented in a descriptive analysis.
A total of 80 540 requests for anti-SS-B antibody testing were carried out over a period of 7.9 years. Anti-SS-B positivity was found in 1693 patients. Among them, 335 (19.8%) patients had isolated anti-SS-B in ELISA/ALBIA. Immunodot was performed in 186 of them and confirmed anti-SS-B positivity in 61 patients (3.6% of anti-SS-B positivity). 24 patients (39.3%) presented with a history of various autoimmune or autoinflammatory diseases and only 6 were diagnosed with a new connective tissue disease. After a median follow-up of 26 months, only two new diagnoses were made.
Anti-SS-B without anti-SS-A is exceedingly rare when accurately identified by a rigorous immunological approach. The initial anti-SS-B positivity does not correlate with a specific condition, both at the time of initial identification and after a 26-month follow-up period. This supports the fact that isolated anti-SS-B has no diagnostic or prognostic value.
在干燥综合征中，抗SS - B抗体常与抗SS - A抗体相关。与抗SS - A抗体阳性相比，抗SS - B阳性/抗SS - A阴性的免疫表型的意义仍存在争议。我们旨在评估孤立性抗SS - B抗体的患病率及诊断意义。
我们对巴黎公立医院集团的三家医院进行了一项回顾性研究。使用酶联免疫吸附测定（ELISA）、可寻址激光束免疫测定（ALBIA）和免疫斑点试验来识别抗SS - B阳性的患者。如果两种技术检测抗SS - B均为阳性且抗SS - A为阴性，则纳入研究。提取临床、生物学和免疫学数据并进行描述性分析。
在7.9年的时间里，共进行了80540次抗SS - B抗体检测。1693例患者抗SS - B呈阳性。其中，335例（19.8%）患者在ELISA/ALBIA检测中为孤立性抗SS - B阳性。对其中186例进行了免疫斑点试验，61例（抗SS - B阳性患者的3.6%）证实抗SS - B阳性。24例（39.3%）患者有各种自身免疫性或自身炎症性疾病史，仅6例被诊断为新的结缔组织病。中位随访26个月后仅做出2例新诊断。
通过严格的免疫学方法准确识别时，无抗SS - A的抗SS - B极为罕见。最初抗SS - B阳性在初次识别时以及26个月的随访期后均与特定疾病无关。这支持了孤立性抗SS - B无诊断或预后价值这一事实。
