Li Yinshuang, El-Sehrawy Amr Ali Mohamed Abdelgawwad, Shankar Amar, Srivastava Manish, Mohammed Jaafaru Sani, Hjazi Ahmed, Singh Mandeep, Sapaev I B, Mustafa Yasser Fakri, Abosaoda Munther Kadhim
Institute of Medical Technology, Chuxiong Medical College, Chuxiong, Yunnan, China.
Department of Internal Medicine, Diabetes, Endocrinology and Metabolism, Mansoura University, Mansoura, Egypt.
Clin Ther. 2025 Mar;47(3):235-243. doi: 10.1016/j.clinthera.2024.12.010. Epub 2025 Feb 3.
Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant that has been suggested to have beneficial effects on lipid profiles and blood pressure. This systematic review and meta-analysis aim to evaluate the effects of CoQ10 supplementation on these parameters in patients with Type 2 Diabetes (T2D).
To assess the impact of CoQ10 supplementation on lipid profiles and blood pressure in individuals diagnosed with Type 2 Diabetes.
A systematic literature search was conducted in databases such as PubMed, Cochrane Library, and Scopus for randomized controlled trials (RCTs) published up to July 2024. Studies included were those that examined the effects of CoQ10 supplementation on lipid profiles (total cholesterol, LDL, HDL, triglycerides) and blood pressure (systolic and diastolic) in T2D patients.
16 studies were included. CoQ10supplementation reduced SBP (WMD: -3.86 mmHg, 95% CI: -6.01 to -1.71, P = 0.014, I = 83.7%; P < 0.001) and DBP (WMD: -2.70 mmHg, 95% CI: -4.50 to -0.91, P = 0.024, I = 92.1%; P < 0.001), but did not change lipid profile. Additionally, subgroup analysis indicated that the effects of CoQ10 on lipid profiles levels were more pronounced in studies where the daily dosage of CoQ10 was 100 mg or less, and the duration of the study was under 12 weeks.
Coenzyme Q10 supplementation appears to have a beneficial effect on lipid profiles and may contribute to lowering blood pressure in patients with Type 2 Diabetes. These findings suggest that CoQ10 could be a valuable adjunctive therapy for managing cardiovascular risk in this population. Additional in-depth research is needed to validate these findings and understand the underlying mechanisms in more detail.
辅酶Q10（CoQ10）是一种天然存在的抗氧化剂，有人认为它对血脂和血压有有益影响。本系统评价和荟萃分析旨在评估补充CoQ10对2型糖尿病（T2D）患者这些参数的影响。
评估补充CoQ10对2型糖尿病患者血脂和血压的影响。
在PubMed、Cochrane图书馆和Scopus等数据库中进行系统文献检索，以查找截至2024年7月发表的随机对照试验（RCT）。纳入的研究是那些考察补充CoQ10对T2D患者血脂（总胆固醇、低密度脂蛋白、高密度脂蛋白、甘油三酯）和血压（收缩压和舒张压）影响的研究。
纳入16项研究。补充CoQ10可降低收缩压（加权均数差：-3.86 mmHg，95%置信区间：-6.01至-1.71，P = 0.014，I² = 83.7%；P < 0.001）和舒张压（加权均数差：-2.70 mmHg，95%置信区间：-4.50至-0.91，P = 0.024，I² = 92.1%；P < 0.001），但对血脂无影响。此外，亚组分析表明，在CoQ10日剂量为100 mg或更低且研究持续时间在12周以下的研究中，CoQ10对血脂水平的影响更为显著。
补充辅酶Q10似乎对血脂有有益影响，可能有助于降低2型糖尿病患者的血压。这些发现表明，CoQ10可能是该人群管理心血管风险的一种有价值的辅助治疗方法。需要进一步深入研究以验证这些发现并更详细地了解其潜在机制。
